| Title: | Associations of Intrapancreatic Fat Deposition With Incident Diseases of the Exocrine and Endocrine Pancreas: A UK Biobank Prospective Cohort Study. |
| Journal: | The American Journal of Gastroenterology |
| Published: | 26 Apr 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38587286/ |
| DOI: | https://doi.org/10.14309/ajg.0000000000002792 |
| URL: | https://journals.lww.com/ajg/abstract/9900/associations_of_intra_pancreatic_fat_deposition.1101.aspx |
Publication 9804
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Abstract
INTRODUCTION: To investigate whether increased intrapancreatic fat deposition (IPFD) heightens the risk of diseases of the exocrine and endocrine pancreas.</p>
METHODS: A prospective cohort study was conducted using data from the UK Biobank. IPFD was quantified using MRI and a deep learning-based framework called nnUNet. The prevalence of fatty change of the pancreas (FP) was determined using sex- and age-specific thresholds. Associations between IPFD and pancreatic diseases were assessed with multivariate Cox-proportional hazard model adjusted for age, sex, ethnicity, body mass index, smoking and drinking status, central obesity, hypertension, dyslipidemia, liver fat content, and spleen fat content.</p>
RESULTS: Of the 42,599 participants included in the analysis, the prevalence of FP was 17.86%. Elevated IPFD levels were associated with an increased risk of acute pancreatitis (hazard ratio [HR] per 1 quintile change 1.513, 95% confidence interval [CI] 1.179-1.941), pancreatic cancer (HR per 1 quintile change 1.365, 95% CI 1.058-1.762) and diabetes mellitus (HR per 1 quintile change 1.221, 95% CI 1.132-1.318). FP was also associated with a higher risk of acute pancreatitis (HR 3.982, 95% CI 2.192-7.234), pancreatic cancer (HR 1.976, 95% CI 1.054-3.704), and diabetes mellitus (HR 1.337, 95% CI 1.122-1.593, P = 0.001).</p>
DISCUSSION: FP is a common pancreatic disorder. Fat in the pancreas is an independent risk factor for diseases of both the exocrine pancreas and endocrine pancreas.</p>
17 Authors
- Xiaowu Dong
- Qingtian Zhu
- Chenchen Yuan
- Yaodong Wang
- Xiaojie Ma
- Xiaolei Shi
- Weiwei Chen
- Zhao Dong
- Lin Chen
- Qinhao Shen
- Hongwei Xu
- Yanbing Ding
- Weijuan Gong
- Weiming Xiao
- Shengfeng Wang
- Weiqin Li
- Guotao Lu
1 Application
| Application ID | Title |
|---|---|
| 69476 | The genetic architecture and enviromental risk factors of pancreatitis. |
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