| Title: | Meaning in life and Parkinson's disease in the UK Biobank |
| Journal: | Clinical Parkinsonism & Related Disorders |
| Published: | 27 Dec 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38234675/ |
| DOI: | https://doi.org/10.1016/j.prdoa.2023.100231 |
Publication 9055
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Abstract
Introduction: Meaning in life is an aspect of eudaimonic well-being associated with lower dementia risk. This research examines whether this protective association extends to Parkinson's disease (PD).</p>
Methods: Participants (N = 153,569) from the UK Biobank reported on their meaning in life. Cases of PD were identified through health records.</p>
Results: Meaning in life was associated with a 50 % lower likelihood of prevalent PD (OR = 0.68, 95 % CI = 0.59-0.78). Over the 5-year follow-up, meaning was associated with a 35 % lower risk of incident PD (HR = 0.74, 95 % CI = 0.65-0.83), an association robust to sociodemographic characteristics, depression, history of seeking mental health care, smoking, physical activity, and genetic risk and not moderated by age, sex, education, deprivation, or genetic risk.</p>
Conclusions: Meaning in life is associated with lower risk of incident PD, an association independent of other major risk factors and generalizable across sociodemographic groups. Meaning is a promising target of intervention for common neurodegenerative diseases.</p>
4 Authors
- Angelina R. Sutin
- Martina Luchetti
- Yannick Stephan
- Antonio Terracciano
1 Application
| Application ID | Title |
|---|---|
| 57672 | Linking psychological well-being measures to brain and health biomarkers to understand aging and risk of dementia |
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