| Title: | Use of statins and risks of ovarian, uterine, and cervical diseases: a cohort study in the UK Biobank |
| Journal: | European Journal of Clinical Pharmacology |
| Published: | 28 Feb 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38416166/ |
| DOI: | https://doi.org/10.1007/s00228-024-03656-y |
| URL: | https://link.springer.com/content/pdf/10.1007/s00228-024-03656-y.pdf |
Publication 8640
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Abstract
PurposeTo examine the associations between use of statins and risks of various ovarian, uterine, and cervical diseases, including ovarian cancer, endometrial cancer, cervical cancer, ovarian cyst, polycystic ovarian syndrome, endometriosis, endometrial hyperplasia, endometrial polyp, and cervical polyp.MethodsWe conducted a cohort study among female participants in the UK Biobank. Information on the use of statins was collected through verbal interview. Outcome information was obtained by linking to national cancer registry data and hospital inpatient data. We used Cox proportional hazards regression to examine the associations.ResultsA total of 180,855 female participants (18,403 statin users and 162,452 non-users) were included. Use of statins was significantly associated with increased risks of cervical cancer (adjusted hazard ratio (HR), 1.55; 95% confidence interval (95% CI), 1.05-2.30) and polycystic ovarian syndrome (adjusted HR, 4.39; 95% CI, 1.68-11.49). However, we observed no significant association between use of statins and risk of ovarian cancer, endometrial cancer, ovarian cyst, endometriosis, endometrial hyperplasia, endometrial polyp, or cervical polyp.ConclusionOur findings suggest that use of statins is associated with increased risks of cervical cancer and polycystic ovarian syndrome, but is not associated with increased or decreased risk of ovarian cancer, endometrial cancer, ovarian cyst, endometriosis, endometrial polyp, or cervical polyp.</p>
11 Authors
- Xue-Feng Jiao
- Hailong Li
- Linan Zeng
- Huazhen Yang
- Yao Hu
- Yuanyuan Qu
- Wenwen Chen
- Yajing Sun
- Wei Zhang
- Xiaoxi Zeng
- Lingli Zhang
1 Application
| Application ID | Title |
|---|---|
| 54803 | Deciphering complex traits - phenotypic and genetic associations between traits in the UK Biobank Cohort |
Enabling scientific discoveries that improve human health