| Title: | Accelerometer-derived physical activity and the risk of death, heart failure, and stroke in patients with atrial fibrillation: a prospective study from UK Biobank |
| Journal: | British Journal of Sports Medicine |
| Published: | 28 Feb 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38418213/ |
| DOI: | https://doi.org/10.1136/bjsports-2023-106862 |
| URL: | https://bjsm.bmj.com/content/bjsports/early/2024/02/28/bjsports-2023-106862.full.pdf |
Publication 8638
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Abstract
OBJECTIVE: Data on cardiovascular outcomes according to objectively measured physical activity (PA) in patients with atrial fibrillation (AF) are scarce. This study explored the associations between PA derived from wrist-worn accelerometers and the risk of death, incident heart failure (HF), and incident stroke in patients with AF.</p>
METHODS: From 37 990 patients with AF in UK Biobank, 2324 patients with accelerometer data were included. Weekly moderate-to-vigorous PA (MVPA) duration was computed from accelerometer data. The primary outcome was all-cause mortality. Secondary outcomes were cardiovascular mortality, incident HF, and incident stroke. Restricted cubic splines estimated the dose-response associations between MVPA duration and the outcomes. The adjusted HRs (aHRs) of the outcomes according to adherence to PA standard guidelines (performing MVPA≥150 min/week) were also evaluated.</p>
RESULTS: The mean age was 66.9±6.2 years and 64.9% were male. During a median follow-up of 6.7 years, there were 181 all-cause deaths, 62 cardiovascular deaths, 225 cases of incident HF, and 91 cases of incident stroke; the overall incidence rate per 1000 patient-years was 11.76, 4.03, 15.16 and 5.99, respectively. There was a linear inverse dose-response relationship between MVPA (≥108 min/week) and all-cause mortality. Performing MVPA for 105-590 min/week was associated with a lower risk of HF than those with no measurable MVPA. The risk of stroke and cardiovascular mortality was not associated with MVPA. Performing guideline-adherent MVPA was related to a 30% lower risk of all-cause mortality (aHR: 0.70 (0.50-0.98), p=0.04) and 33% lower risk of HF (aHR 0.67 (0.49-0.93), p=0.02).</p>
CONCLUSION: In patients with AF, accelerometer-derived PA data supports lower risks of all-cause mortality and HF according to a greater level of MVPA and adherence to PA guidelines. Regular MVPA should be encouraged in patients with AF as a part of integrated management.</p>
9 Authors
- Hyo-Jeong Ahn
- Eue-Keun Choi
- Tae-Min Rhee
- JungMin Choi
- Kyung-Yeon Lee
- Soonil Kwon
- So-Ryoung Lee
- Seil Oh
- Gregory Y H Lip
1 Application
| Application ID | Title |
|---|---|
| 76593 | Anthropometric characteristics and the risk of atrial fibrillation and cardiovascular diseases in different age groups |
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