| Title: | Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants |
| Journal: | Nature Genetics |
| Published: | 9 Nov 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37945903/ |
| DOI: | https://doi.org/10.1038/s41588-023-01534-4 |
Publication 8356
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Abstract
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.</p>
291 Authors
- Anqi Wang
- Jiayi Shen
- Alex A. Rodriguez
- Edward J. Saunders
- Fei Chen
- Rohini Janivara
- Burcu F. Darst
- Xin Sheng
- Yili Xu
- Alisha J. Chou
- Sara Benlloch
- Tokhir Dadaev
- Mark N. Brook
- Anna Plym
- Ali Sahimi
- Thomas J. Hoffman
- Atushi Takahashi
- Koichi Matsuda
- Yukihide Momozawa
- Masashi Fujita
- Triin Laisk
- Jéssica Figuerêdo
- Kenneth Muir
- Shuji Ito
- Xiaoxi Liu
- Yuji Uchio
- Michiaki Kubo
- Yoichiro Kamatani
- Artitaya Lophatananon
- Peggy Wan
- Caroline Andrews
- Adriana Lori
- Parichoy P. Choudhury
- Johanna Schleutker
- Teuvo L. J. Tammela
- Csilla Sipeky
- Anssi Auvinen
- Graham G. Giles
- Melissa C. Southey
- Robert J. MacInnis
- Cezary Cybulski
- Dominika Wokolorczyk
- Jan Lubinski
- Christopher T. Rentsch
- Kelly Cho
- Benjamin H. Mcmahon
- David E. Neal
- Jenny L. Donovan
- Freddie C. Hamdy
- Richard M. Martin
- Borge G. Nordestgaard
- Sune F. Nielsen
- Maren Weischer
- Stig E. Bojesen
- Andreas Røder
- Hein V. Stroomberg
- Jyotsna Batra
- Suzanne Chambers
- Lisa Horvath
- Judith A. Clements
- Wayne Tilly
- Gail P. Risbridger
- Henrik Gronberg
- Markus Aly
- Robert Szulkin
- Martin Eklund
- Tobias Nordstrom
- Nora Pashayan
- Alison M. Dunning
- Maya Ghoussaini
- Ruth C. Travis
- Tim J. Key
- Elio Riboli
- Jong Y. Park
- Thomas A. Sellers
- Hui-Yi Lin
- Demetrius Albanes
- Stephanie Weinstein
- Michael B. Cook
- Lorelei A. Mucci
- Edward Giovannucci
- Sara Lindstrom
- Peter Kraft
- David J. Hunter
- Kathryn L. Penney
- Constance Turman
- Catherine M. Tangen
- Phyllis J. Goodman
- Ian M. Thompson
- Robert J. Hamilton
- Neil E. Fleshner
- Antonio Finelli
- Marie-Élise Parent
- Janet L. Stanford
- Elaine A. Ostrander
- Stella Koutros
- Laura E. Beane Freeman
- Meir Stampfer
- Alicja Wolk
- Niclas Håkansson
- Gerald L. Andriole
- Robert N. Hoover
- Mitchell J. Machiela
- Karina Dalsgaard Sørensen
- Michael Borre
- William J. Blot
- Wei Zheng
- Edward D. Yeboah
- James E. Mensah
- Yong-Jie Lu
- Hong-Wei Zhang
- Ninghan Feng
- Xueying Mao
- Yudong Wu
- Shan-Chao Zhao
- Zan Sun
- Stephen N. Thibodeau
- Shannon K. McDonnell
- Daniel J. Schaid
- Catharine M. L. West
- Gill Barnett
- Christiane Maier
- Thomas Schnoeller
- Manuel Luedeke
- Adam S. Kibel
- Bettina F. Drake
- Olivier Cussenot
- Geraldine Cancel-Tassin
- Florence Menegaux
- Thérèse Truong
- Yves Akoli Koudou
- Esther M. John
- Eli Marie Grindedal
- Lovise Maehle
- Kay-Tee Khaw
- Sue A. Ingles
- Mariana C. Stern
- Ana Vega
- Antonio Gómez-Caamaño
- Laura Fachal
- Barry S. Rosenstein
- Sarah L. Kerns
- Harry Ostrer
- Manuel R. Teixeira
- Paula Paulo
- Andreia Brandão
- Stephen Watya
- Alexander Lubwama
- Jeannette T. Bensen
- Ebonee N. Butler
- James L. Mohler
- Jack A. Taylor
- Manolis Kogevinas
- Trinidad Dierssen-Sotos
- Gemma Castaño-Vinyals
- Lisa Cannon-Albright
- Craig C. Teerlink
- Chad D. Huff
- Patrick Pilie
- Yao Yu
- Ryan J. Bohlender
- Jian Gu
- Sara S. Strom
- Luc Multigner
- Pascal Blanchet
- Laurent Brureau
- Radka Kaneva
- Chavdar Slavov
- Vanio Mitev
- Robin J. Leach
- Hermann Brenner
- Xuechen Chen
- Bernd Holleczek
- Ben Schöttker
- Eric A. Klein
- Ann W. Hsing
- Rick A. Kittles
- Adam B. Murphy
- Christopher J. Logothetis
- Jeri Kim
- Susan L. Neuhausen
- Linda Steele
- Yuan Chun Ding
- William B. Isaacs
- Barbara Nemesure
- Anselm J. M. Hennis
- John Carpten
- Hardev Pandha
- Agnieszka Michael
- Kim De Ruyck
- Gert De Meerleer
- Piet Ost
- Jianfeng Xu
- Azad Razack
- Jasmine Lim
- Soo-Hwang Teo
- Lisa F. Newcomb
- Daniel W. Lin
- Jay H. Fowke
- Christine M. Neslund-Dudas
- Benjamin A. Rybicki
- Marija Gamulin
- Davor Lessel
- Tomislav Kulis
- Nawaid Usmani
- Aswin Abraham
- Sandeep Singhal
- Matthew Parliament
- Frank Claessens
- Steven Joniau
- Thomas Van den Broeck
- Manuela Gago-Dominguez
- Jose Esteban Castelao
- Maria Elena Martinez
- Samantha Larkin
- Paul A. Townsend
- Claire Aukim-Hastie
- William S. Bush
- Melinda C. Aldrich
- Dana C. Crawford
- Shiv Srivastava
- Jennifer Cullen
- Gyorgy Petrovics
- Graham Casey
- Ying Wang
- Yao Tettey
- Joseph Lachance
- Wei Tang
- Richard B. Biritwum
- Andrew A. Adjei
- Evelyn Tay
- Ann Truelove
- Shelley Niwa
- Kosj Yamoah
- Koveela Govindasami
- Anand P. Chokkalingam
- Jacob M. Keaton
- Jacklyn N. Hellwege
- Peter E. Clark
- Mohamed Jalloh
- Serigne M. Gueye
- Lamine Niang
- Olufemi Ogunbiyi
- Olayiwola Shittu
- Olukemi Amodu
- Akindele O. Adebiyi
- Oseremen I. Aisuodionoe-Shadrach
- Hafees O. Ajibola
- Mustapha A. Jamda
- Olabode P. Oluwole
- Maxwell Nwegbu
- Ben Adusei
- Sunny Mante
- Afua Darkwa-Abrahams
- Halimatou Diop
- Susan M. Gundell
- Monique J. Roobol
- Guido Jenster
- Ron H. N. van Schaik
- Jennifer J. Hu
- Maureen Sanderson
- Linda Kachuri
- Rohit Varma
- Roberta McKean-Cowdin
- Mina Torres
- Michael H. Preuss
- Ruth J. F. Loos
- Matthew Zawistowski
- Sebastian Zöllner
- Zeyun Lu
- Stephen K. Van Den Eeden
- Douglas F. Easton
- Stefan Ambs
- Todd L. Edwards
- Reedik Mägi
- Timothy R. Rebbeck
- Lars Fritsche
- Stephen J. Chanock
- Sonja I. Berndt
- Fredrik Wiklund
- Hidewaki Nakagawa
- John S. Witte
- J. Michael Gaziano
- Amy C. Justice
- Nick Mancuso
- Chikashi Terao
- Rosalind A. Eeles
- Zsofia Kote-Jarai
- Ravi K. Madduri
- David V. Conti
- Christopher A. Haiman
1 Application
| Application ID | Title |
|---|---|
| 42195 | GWAS Meta-Analysis of T2D and Prostate Cancer |
Enabling scientific discoveries that improve human health