| Title: | Impact of Maternal Smoking, Offspring Smoking, and Genetic Susceptibility on Crohn's Disease and Ulcerative Colitis |
| Journal: | Journal of Crohn's and Colitis |
| Published: | 1 Dec 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38038665/ |
| DOI: | https://doi.org/10.1093/ecco-jcc/jjad200 |
Publication 8223
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND AND AIMS: The long-term impact of maternal smoking during pregnancy (MSDP) on adult offspring's risk of Crohn's disease (CD) and ulcerative colitis (UC) remains uncertain. Our study aims to investigate the individual and combined effects of early life exposure (MSDP), offspring personal behavior (smoking), and genetic risk on the development of CD and UC in adult offspring.</p>
METHODS: We conducted a prospective cohort study using UK Biobank data, including 334,083 participants recruited between 2006-2010, with follow-up until December 31, 2021. Multivariable Cox regression models were used to evaluate the associations of genetic factors, maternal and personal smoking, and their combination with CD and UC.</p>
RESULTS: Participants exposed to MSDP had an 18% increased risk of CD compared to those without MSDP (hazard ratio (HR) = 1.18, 95% confidence interval (CI) = 1.01-1.39). However, no significant association was found between MSDP and the UC risk (HR = 1.03, 95%CI = 0.92-1.16). Personal smoking increased the risk of CD and UC, and had a numerically amplified effect with MSDP. Participants with high genetic risk and MSDP had a 2.01-fold (95%CI = 1.53-2.65) and a 2.45-fold (95%CI = 2.00-2.99) increased risk of CD and UC, respectively, compared to participants without MSDP and with low genetic risk.</p>
CONCLUSIONS: Our prospective cohort study provides evidence that MSDP increases the risk of CD in adult offspring, whereas no evidence supports their causal association. Additionally, smoking and genetic susceptibility had a numerically amplified effect with MSDP on CD and UC, but the interaction lacked statistical significance.</p>
16 Authors
- Linmin Hu
- Siqing Wu
- Yuelong Shu
- Kai Su
- Chunliang Wang
- Danni Wang
- Qiangsheng He
- Xinyu Chen
- Wenjing Li
- Ningning Mi
- Peng Xie
- Jinyu Zhao
- Shiyong Zhang
- Jinqiu Yuan
- Jianbang Xiang
- Bin Xia
1 Application
| Application ID | Title |
|---|---|
| 51671 | Metabolism syndrome and risk of cancer |
Enabling scientific discoveries that improve human health