| Title: | COVID-19 related outcomes among individuals with neurodegenerative diseases: a cohort analysis in the UK biobank |
| Journal: | BMC Neurology |
| Published: | 7 Jan 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34996388/ |
| DOI: | https://doi.org/10.1186/s12883-021-02536-7 |
| URL: | https://bmcneurol.biomedcentral.com/counter/pdf/10.1186/s12883-021-02536-7 |
Publication 8180
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Abstract
BackgroundAn increased susceptibility to COVID-19 has been suggested for individuals with neurodegenerative diseases, but data are scarce from longitudinal studies.MethodsIn this community-based cohort study, we included 96,275 participants of the UK Biobank who had available SARS-CoV-2 test results in Public Health England. Of these, 2617 had a clinical diagnosis of neurodegenerative diseases in the UK Biobank inpatient hospital data before the outbreak of COVID-19 (defined as January 31st, 2020), while the remaining participants constituted the reference group. We then followed both groups from January 31st, 2020 to June 14th, 2021 for ascertainment of COVID-19 outcomes, including any COVID-19, inpatient care for COVID-19, and COVID-19 related death. Logistic regression was applied to estimate the association between neurogenerative disease and risks of COVID-19 outcomes, adjusted for multiple confounders and somatic comorbidities.ResultsWe observed an elevated risk of COVID-19 outcomes among individuals with a neurodegenerative disease compared with the reference group, corresponding to a fully adjusted odds ratio of 2.47 (95%CI 2.25-2.71) for any COVID-19, 2.18 (95%CI 1.94-2.45) for inpatient COVID-19, and 3.67 (95%CI 3.11-4.34) for COVID-19 related death. Among individuals with a positive test result for SARS-CoV-2, individuals with neurodegenerative diseases had also a higher risk of COVID-19 related death than others (fully adjusted odds ratio 2.08; 95%CI 1.71-2.53).ConclusionAmong UK Biobank participants who received at least one test for SARS-CoV-2, a pre-existing diagnosis of neurodegenerative disease was associated with a subsequently increased risk of COVID-19, especially COVID-19 related death.13 Authors
- Yihan Hu
- Huazhen Yang
- Can Hou
- Wenwen Chen
- Hanyue Zhang
- Zhiye Ying
- Yao Hu
- Yajing Sun
- Yuanyuan Qu
- Maria Feychting
- Unnur Valdimarsdottir
- Huan Song
- Fang Fang
1 Application
| Application ID | Title |
|---|---|
| 54803 | Deciphering complex traits - phenotypic and genetic associations between traits in the UK Biobank Cohort |
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