| Title: | The Contribution of Genetic Risk and Lifestyle Factors in the Development of Adult-Onset Inflammatory Bowel Disease: A Prospective Cohort Study |
| Journal: | The American Journal of Gastroenterology |
| Published: | 9 Jan 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36695739/ |
| DOI: | https://doi.org/10.14309/ajg.0000000000002180 |
| URL: | https://journals.lww.com/ajg/Fulltext/2023/03000/The_Contribution_of_Genetic_Risk_and_Lifestyle.31.aspx |
Publication 7996
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Abstract
INTRODUCTION: The joint associations across genetic risk, modifiable lifestyle factors, and inflammatory bowel disease (IBD) remains unclear. METHODS: Genetic susceptibility to Crohn's disease (CD) and ulcerative colitis (UC) was estimated by polygenic risk scores and further categorized into high, intermediate, and low genetic risk categories. Weighted healthy lifestyle scores were constructed based on 5 common lifestyle factors and categorized into favorable (4 or 5 healthy lifestyle factors), intermediate (3 healthy lifestyle factors), and unfavorable (0-2 healthy lifestyle factors) groups. Cox proportional hazards regression model was used to estimate the hazard ratios (HR) and 95% confidence interval (CI) for their associations. RESULTS: During the 12-year follow-up, 707 cases with CD and 1576 cases with UC were diagnosed in the UK Biobank cohort. Genetic risk and unhealthy lifestyle categories were monotonically associated with CD and UC risk with no multiplicative interaction between them. The HR of CD and UC were 2.24 (95% CI 1.75-2.86) and 2.15 (95% CI 1.82-2.53) for those with a high genetic risk, respectively. The HR of CD and UC for individuals with an unfavorable lifestyle were 1.94 (95% CI 1.61-2.33) and 1.98 (95% CI 1.73-2.27), respectively. The HR of individuals with a high genetic risk but a favorable lifestyle (2.33, 95% CI 1.58-3.44 for CD, and 2.05, 95% CI 1.58-2.66 for UC) were reduced nearly by half, compared with those with a high genetic risk but an unfavorable lifestyle (4.40, 95% CI 2.91-6.66 for CD and 4.44, 95% CI 3.34-5.91 for UC). DISCUSSION: Genetic and lifestyle factors were independently associated with susceptibility to incident CD and UC. Adherence to a favorable lifestyle was associated with a nearly 50% lower risk of CD and UC among participants at a high genetic risk.20 Authors
- Yuhao Sun
- Shuai Yuan
- Xuejie Chen
- Jing Sun
- Rahul Kalla
- Lili Yu
- Lijuan Wang
- Xuan Zhou
- Xiangxing Kong
- Therese Hesketh
- Gwo-tzer Ho
- Kefeng Ding
- Malcolm Dunlop
- Susanna C. Larsson
- Jack Satsangi
- Jie Chen
- Xiaoyan Wang
- Xue Li
- Evropi Theodoratou
- Edward L. Giovannucci
1 Application
| Application ID | Title |
|---|---|
| 66354 | Investigating the genetic, environmental and clinical determinants and their interactions on cancer risk, and developing risk prediction and prognosis models for common cancer types |
Enabling scientific discoveries that improve human health