| Title: | Cardiovascular disease risk assessment using a deep-learning-based retinal biomarker: a comparison with existing risk scores |
| Journal: | European Heart Journal - Digital Health |
| Published: | 28 Mar 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37265875/ |
| DOI: | https://doi.org/10.1093/ehjdh/ztad023 |
| URL: | https://academic.oup.com/ehjdh/advance-article-pdf/doi/10.1093/ehjdh/ztad023/49662044/ztad023.pdf |
Publication 7890
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Abstract
Aims: This study aims to evaluate the ability of a deep-learning-based cardiovascular disease (CVD) retinal biomarker, Reti-CVD, to identify individuals with intermediate- and high-risk for CVD. Methods and results: We defined the intermediate- and high-risk groups according to Pooled Cohort Equation (PCE), QRISK3, and modified Framingham Risk Score (FRS). Reti-CVD's prediction was compared to the number of individuals identified as intermediate- and high-risk according to standard CVD risk assessment tools, and sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated to assess the results. In the UK Biobank, among 48 260 participants, 20 643 (42.8%) and 7192 (14.9%) were classified into the intermediate- and high-risk groups according to PCE, and QRISK3, respectively. In the Singapore Epidemiology of Eye Diseases study, among 6810 participants, 3799 (55.8%) were classified as intermediate- and high-risk group according to modified FRS. Reti-CVD identified PCE-based intermediate- and high-risk groups with a sensitivity, specificity, PPV, and NPV of 82.7%, 87.6%, 86.5%, and 84.0%, respectively. Reti-CVD identified QRISK3-based intermediate- and high-risk groups with a sensitivity, specificity, PPV, and NPV of 82.6%, 85.5%, 49.9%, and 96.6%, respectively. Reti-CVD identified intermediate- and high-risk groups according to the modified FRS with a sensitivity, specificity, PPV, and NPV of 82.1%, 80.6%, 76.4%, and 85.5%, respectively. Conclusion: The retinal photograph biomarker (Reti-CVD) was able to identify individuals with intermediate and high-risk for CVD, in accordance with existing risk assessment tools.18 Authors
- Joseph Keunhong Yi
- Tyler Hyungtaek Rim
- Sungha Park
- Sung Soo Kim
- Hyeon Chang Kim
- Chan Joo Lee
- Hyeonmin Kim
- Geunyoung Lee
- James Soo Ghim Lim
- Yong Yu Tan
- Marco Yu
- Yih-Chung Tham
- Ameet Bakhai
- Eduard Shantsila
- Paul Leeson
- Gregory Y H Lip
- Calvin W L Chin
- Ching-Yu Cheng
1 Application
| Application ID | Title |
|---|---|
| 68428 | Analyses of systemic ageing biomarkers related to retina via deep learning |
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