| Title: | U-shaped association between sleep duration and the risk of respiratory diseases mortality: a large prospective cohort study from UK Biobank. |
| Journal: | Journal of Clinical Sleep Medicine |
| Published: | 1 Nov 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37477156/ |
| DOI: | https://doi.org/10.5664/jcsm.10732 |
Publication 7717
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Abstract
STUDY OBJECTIVES: Our cohort study aimed to study the association between sleep duration and risk of mortality due to respiratory diseases.</p>
METHODS: We included 498,200 participants from UK Biobank (2006-2021). We classified sleep duration as short sleep duration (< 7 hours), long sleep duration (> 9 hours for adults, > 8 hours for older adults), and midrange sleep duration (7-9 hours). We used the Cox proportional hazards model and restricted cubic spline analysis to explore the association between sleep duration and respiratory diseases mortality.</p>
RESULTS: During a median follow-up of 12.49 years, 2,477 deaths due to respiratory diseases were recorded, of which 1,099 were deaths due to chronic lower respiratory diseases. Cox models with penalized splines showed U-shaped associations of sleep duration with mortality due to total respiratory diseases and chronic lower respiratory diseases. Compared with midrange sleep duration, short sleep duration was associated with 14% higher risk of total respiratory diseases mortality (hazard ratio = 1.14; 95% confidence interval: 1.04, 1.25), and long sleep duration was associated with 35% higher risk of total respiratory diseases mortality (hazard ratio = 1.35; 95% confidence interval: 1.19, 1.55), after adjustment of baseline characteristics, health status, and lifestyle habits. Similarly, the hazard ratios for chronic lower respiratory diseases mortality were 1.20 (95% confidence interval: 1.04, 1.38) and 1.44 (95% confidence interval: 1.19, 1.74), respectively.</p>
CONCLUSIONS: There was a U-shaped association between sleep duration and respiratory diseases mortality. Appropriate sleep duration may improve the progress of respiratory diseases.</p>
CITATION: Du M, Liu M, Liu J. U-shaped association between sleep duration and the risk of respiratory diseases mortality: a large prospective cohort study from UK Biobank. J Clin Sleep Med. 2023;19(11):1923-1932.</p>
3 Authors
- Min Du
- Min Liu
- Jue Liu
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