| Title: | Highly accurate and precise automated cup-to-disc ratio quantification for glaucoma screening |
| Journal: | Ophthalmology Science |
| Published: | 1 Apr 2024 |
| DOI: | https://doi.org/10.1016/j.xops.2024.100540 |
| URL: | http://dx.doi.org/10.1016/j.xops.2024.100540 |
Publication 9993
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Abstract
Objective An enlarged cup-to-disc ratio (CDR) is a hallmark of glaucomatous optic neuropathy. Manual assessment of the CDR may be less accurate and more time-consuming than automated methods. Here, we sought to develop and validate a deep-learning-based algorithm to automatically determine the CDR from fundus images. Design Algorithm development for estimating CDR using fundus data from a population-based observational study. Participants A total of 181,768 fundus images from the UK Biobank, Drishti_GS, and EyePACS. Main Outcome Measures The area under the receiver operating characteristic curve (AUROC) and coefficient of determination (R 2 ). Methods FastAI and PyTorch libraries were used to train a convolutional neural network-based model on fundus images from the UK Biobank. Models were constructed to determine image gradability (classification analysis) as well as to estimate CDR (regression analysis). The best-performing model was then validated for use in glaucoma screening using a multiethnic dataset from EyePACS and Drishti_GS. Results Our gradability model vgg19_bn achieved an accuracy of 97.13% on a validation set of 16,045 images, with 99.26% precision and AUROC of 96.56%. Using regression analysis, our best-performing model (trained on the vgg19_bn architecture) attained an R 2 of 0.8514 (95% CI: 0.8459-0.8568), while the mean squared error was 0.0050 (95% CI: 0.0048-0.0051) and mean absolute error was 0.0551 (95% CI: 0.0543-0.0559) on a validation set of 12,183 images for determining CDR. The regression point was converted into classification metrics using a tolerance of 0.2 for 20 classes; the classification metrics achieved an accuracy of 99.20%. The EyePACS dataset (98172 healthy, 3270 glaucoma) was then used to externally validate the model for glaucoma classification, with an accuracy, sensitivity and specificity of 82.49%, 72.02% and 82.83%, respectively. Conclusions Our models were precise in determining image gradability and estimating CDR. Although our AI-derived CDR estimates achieve high accuracy, the CDR threshold for glaucoma screening will vary depending on other clinical parameters.</p>
8 Authors
- Abadh K. Chaurasia
- Connor J. Greatbatch
- Xikun Han
- Puya Gharahkhani
- David A. Mackey
- Stuart MacGregor
- Jamie E. Craig
- Alex W. Hewitt
1 Application
| Application ID | Title |
|---|---|
| 25331 | Gene mapping and genetic correlation across complex traits |
Enabling scientific discoveries that improve human health