| Title: | Genetic Subtypes of Prediabetes, Healthy Lifestyle, and Risk of Type 2 Diabetes. |
| Journal: | Diabetes |
| Published: | 11 Apr 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38602922/ |
| DOI: | https://doi.org/10.2337/db23-0699 |
| Citations: | 1 (1 in last 2 years) as of 8 Aug 2024 |
Publication 9915
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Abstract
Prediabetes is a heterogenous metabolic state with various risks for development of type 2 diabetes (T2D). In this study, we used genetic data on 7,227 US Hispanic/Latino participants without diabetes from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and 400,149 non-Hispanic White participants without diabetes from the UK Biobank (UKBB) to calculate five partitioned polygenetic risk scores (pPRSs) representing various pathways related to T2D. Consensus clustering was performed in participants with prediabetes in HCHS/SOL (n = 3,677) and UKBB (n = 16,284) separately based on these pPRSs. Six clusters of individuals with prediabetes with distinctive patterns of pPRSs and corresponding metabolic traits were identified in the HCHS/SOL, five of which were confirmed in the UKBB. Although baseline glycemic traits were similar across clusters, individuals in cluster 5 and cluster 6 showed an elevated risk of T2D during follow-up compared with cluster 1 (risk ratios [RRs] 1.29 [95% CI 1.08, 1.53] and 1.34 [1.13, 1.60], respectively). Inverse associations between a healthy lifestyle score and risk of T2D were observed across different clusters, with a suggestively stronger association observed in cluster 5 compared with cluster 1. Among individuals with a healthy lifestyle, those in cluster 5 had a similar risk of T2D compared with those in cluster 1 (RR 1.03 [0.91, 1.18]). This study identified genetic subtypes of prediabetes that differed in risk of progression to T2D and in benefits from a healthy lifestyle.</p>
ARTICLE HIGHLIGHTS: </p>
15 Keywords
- Adult
- Aged
- Diabetes Mellitus, Type 2
- Female
- Genetic Predisposition to Disease
- Healthy Lifestyle
- Hispanic or Latino
- Humans
- Male
- Middle Aged
- Prediabetic State
- Risk Factors
- United Kingdom
- United States
- White People
18 Authors
- Yang Li
- Guo-Chong Chen
- Jee-Young Moon
- Rhonda Arthur
- Daniela Sotres-Alvarez
- Martha L Daviglus
- Amber Pirzada
- Josiemer Mattei
- Krista M Perreira
- Jerome I Rotter
- Kent D Taylor
- Yii-Der Ida Chen
- Sylvia Wassertheil-Smoller
- Tao Wang
- Thomas E Rohan
- Joel D Kaufman
- Robert Kaplan
- Qibin Qi
1 Application
| Application ID | Title |
|---|---|
| 56483 | Diet, metabolic/inflammatory profile and risk of obesity-related chronic conditions among participants in the UK Biobank |
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