| Title: | Sex-dependent associations of plasma high-density lipoprotein cholesterol and mortality risk in healthy older men and women: two prospective cohort studies |
| Journal: | GeroScience |
| Published: | 23 Aug 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37610595/ |
| DOI: | https://doi.org/10.1007/s11357-023-00904-4 |
| URL: | https://link.springer.com/content/pdf/10.1007/s11357-023-00904-4.pdf |
Publication 9715
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
The relationship between high plasma high-density lipoprotein cholesterol (HDL-C) and cause and mortality are not well established in healthy older people. This study examined the associations between HDL-C levels and mortality in initially healthy older men and women. This analysis included participants from the Aspirin in Reducing Events in the Elderly (ASPREE; n=18,668) trial and a matched cohort from the UK Biobank (UKB; n=62,849 ≥65 years). Cox regression was used to examine hazard ratios between HDL-C categories <1.03 mmol/L, 1.03-1.55 mmol/L (referent category), 1.55-2.07 mmol/L, and >2.07 mmol/L and all-cause, cancer, cardiovascular disease (CVD), and "non-cancer non-CVD" mortality. Genetic contributions were assessed using a polygenic score for HDL-C. Among ASPREE participants (aged 75±5 years), 1836 deaths occurred over a mean follow-up of 6.3±1.8 years. In men, the highest category of HDL-C levels was associated with increased risk of all-cause (HR 1.60, 95% CI 1.26-2.03), cancer (HR 1.37, 95% CI 0.96-2.00), and "non-cancer non-CVD" mortality (HR 2.35, 95% CI 1.41-3.42) but not CVD mortality (HR 1.08, 95% CI 0.60-1.94). The associations were replicated among UKB participants (aged 66.9±1.5 years), including 8739 deaths over a mean follow-up of 12.7±0.8 years. There was a non-linear association between HDL-C levels and all-cause and cause-specific mortality. The association between HDL-C levels and mortality was unrelated to variations in the HDL-C polygenic score. No significant association was found between HDL-C levels and mortality in women. Higher HDL-C levels are associated with increased risk from cancer and "non-cancer non-CVD" mortality in healthy older men but no such relationship was observed in women.</p>
11 Authors
- Sultana Monira Hussain
- Andrew M Tonkin
- Gerald F Watts
- Paul Lacaze
- Chenglong Yu
- Lawrence J Beilin
- Zhen Zhou
- Anne B Newman
- Johannes T Neumann
- Cammie Tran
- John J McNeil
1 Application
| Application ID | Title |
|---|---|
| 47061 | Comparing polygenic risk and predicted loss-of-function (pLoF) variants in a healthy ageing cohort (ASPREE) with the UK Biobank, across a range of disease and health-related phenotypes |
Enabling scientific discoveries that improve human health