| Title: | Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank |
| Journal: | Nature Communications |
| Published: | 24 Aug 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37620332/ |
| DOI: | https://doi.org/10.1038/s41467-023-40977-5 |
| URL: | https://www.nature.com/articles/s41467-023-40977-5.pdf |
Publication 9709
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Abstract
Many chronic disease symptomatologies involve desynchronized sleep-wake cycles, indicative of disrupted biorhythms. This can be interrogated using body temperature rhythms, which have circadian as well as sleep-wake behavior/environmental evoked components. Here, we investigated the association of wrist temperature amplitudes with a future onset of disease in the UK Biobank one year after actigraphy. Among 425 disease conditions (range n = 200-6728) compared to controls (range n = 62,107-91,134), a total of 73 (17%) disease phenotypes were significantly associated with decreased amplitudes of wrist temperature (Benjamini-Hochberg FDR q < 0.05) and 26 (6.1%) PheCODEs passed a more stringent significance level (Bonferroni-correction α < 0.05). A two-standard deviation (1.8° Celsius) lower wrist temperature amplitude corresponded to hazard ratios of 1.91 (1.58-2.31 95% CI) for NAFLD, 1.69 (1.53-1.88) for type 2 diabetes, 1.25 (1.14-1.37) for renal failure, 1.23 (1.17-1.3) for hypertension, and 1.22 (1.11-1.33) for pneumonia (phenome-wide atlas available at http://bioinf.itmat.upenn.edu/biorhythm_atlas/). This work suggests peripheral thermoregulation as a digital biomarker.</p>
6 Authors
- Thomas G. Brooks
- Nicholas F. Lahens
- Gregory R. Grant
- Yvette I. Sheline
- Garret A. FitzGerald
- Carsten Skarke
1 Application
| Application ID | Title |
|---|---|
| 50398 | Investigating the interplay between gender and shiftwork in the development of metabolic syndrome |
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