| Title: | Determinants of incident atherosclerotic cardiovascular disease events among individuals with type 2 diabetic microvascular complications in the UK: a prospective cohort study |
| Journal: | Diabetology & Metabolic Syndrome |
| Published: | 29 Aug 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37644580/ |
| DOI: | https://doi.org/10.1186/s13098-023-01152-4 |
| URL: | https://dmsjournal.biomedcentral.com/counter/pdf/10.1186/s13098-023-01152-4 |
| Citations: | 1 (1 in last 2 years) as of 8 Aug 2024 |
Publication 9696
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Abstract
ObjectiveTo evaluate the association of atherosclerotic cardiovascular disease (ASCVD) risk factors with incident ASCVD events among type 2 diabetes (T2D) individuals with microvascular complications.MethodsWe included T2D participants with only microvascular complications from the UK Biobank cohort at baseline (2006-2010). Multivariable-adjusted Cox proportional hazards models were used to study the association between ASCVD risk factors with adjudicated incident ASCVD in T2D participants with only microvascular complications. A restricted cubic spline approach was employed to evaluate potential nonlinear associations between ASCVD risk factors and ASCVD.ResultsWe studied 4,129 T2D individuals with microvascular complications at baseline. Over a median follow-up of 11.7 years, a total of 1,180 cases of incident ASCVD were documented, of which 1,040 were CHD, 100 were stroke, and 40 were both CHD and stroke events. After multivariable-adjustment, high-density lipoprotein cholesterol (HDL-C) level was linearly associated with a decreased risk of incident ASCVD [hazard ratio (HR): 0.49, 95% Confidence interval (CI): 0.32-0.75, Plinear = 0.011] and each 10 nmol/L increase of lipoprotein(a) [Lp(a)] level (HR: 1.02, 95% CI: 1.00-1.04, Plinear = 0.012) was linearly associated with an increased risk of incident ASCVD in T2D participants with only microvascular complications.ConclusionHDL-C levels and Lp(a) levels (per 10 nmol/L) showed an independent linear relation with ASCVD risk among T2D individuals with only microvascular complications at long-term follow-up.</p>
13 Authors
- Yaxin Wang
- Gabriella Bulloch
- Yu Huang
- Yingying Liang
- Zijing Du
- Guanrong Wu
- Ying Fang
- Yijun Hu
- Xianwen Shang
- Zhuoting Zhu
- Xiayin Zhang
- Xiaohong Yang
- Honghua Yu
1 Application
| Application ID | Title |
|---|---|
| 86091 | Regulators of the association between ocular disorders and systemic diseases. |
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