| Title: | Determinants of incident atherosclerotic cardiovascular disease events among individuals with type 2 diabetic microvascular complications in the UK: a prospective cohort study |
| Journal: | Diabetology & Metabolic Syndrome |
| Published: | 29 Aug 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37644580/ |
| DOI: | https://doi.org/10.1186/s13098-023-01152-4 |
| URL: | https://dmsjournal.biomedcentral.com/counter/pdf/10.1186/s13098-023-01152-4 |
Publication 9696
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
ObjectiveTo evaluate the association of atherosclerotic cardiovascular disease (ASCVD) risk factors with incident ASCVD events among type 2 diabetes (T2D) individuals with microvascular complications.MethodsWe included T2D participants with only microvascular complications from the UK Biobank cohort at baseline (2006-2010). Multivariable-adjusted Cox proportional hazards models were used to study the association between ASCVD risk factors with adjudicated incident ASCVD in T2D participants with only microvascular complications. A restricted cubic spline approach was employed to evaluate potential nonlinear associations between ASCVD risk factors and ASCVD.ResultsWe studied 4,129 T2D individuals with microvascular complications at baseline. Over a median follow-up of 11.7 years, a total of 1,180 cases of incident ASCVD were documented, of which 1,040 were CHD, 100 were stroke, and 40 were both CHD and stroke events. After multivariable-adjustment, high-density lipoprotein cholesterol (HDL-C) level was linearly associated with a decreased risk of incident ASCVD [hazard ratio (HR): 0.49, 95% Confidence interval (CI): 0.32-0.75, Plinear = 0.011] and each 10 nmol/L increase of lipoprotein(a) [Lp(a)] level (HR: 1.02, 95% CI: 1.00-1.04, Plinear = 0.012) was linearly associated with an increased risk of incident ASCVD in T2D participants with only microvascular complications.ConclusionHDL-C levels and Lp(a) levels (per 10 nmol/L) showed an independent linear relation with ASCVD risk among T2D individuals with only microvascular complications at long-term follow-up.</p>
13 Authors
- Yaxin Wang
- Gabriella Bulloch
- Yu Huang
- Yingying Liang
- Zijing Du
- Guanrong Wu
- Ying Fang
- Yijun Hu
- Xianwen Shang
- Zhuoting Zhu
- Xiayin Zhang
- Xiaohong Yang
- Honghua Yu
1 Application
| Application ID | Title |
|---|---|
| 86091 | Regulators of the association between ocular disorders and systemic diseases. |
Enabling scientific discoveries that improve human health