| Title: | Ethnic differences of genetic risk and smoking in lung cancer: two prospective cohort studies |
| Journal: | International Journal of Epidemiology |
| Published: | 7 Sep 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37676847/ |
| DOI: | https://doi.org/10.1093/ije/dyad118 |
| URL: | https://doi.org/10.1101/2023.02.09.23285130 |
Publication 9612
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: The role of genetic background underlying the disparity of relative risk of smoking and lung cancer between European populations and East Asians remains unclear.</p>
METHODS: To assess the role of ethnic differences in genetic factors associated with smoking-related risk of lung cancer, we first constructed ethnic-specific polygenic risk scores (PRSs) to quantify individual genetic risk of lung cancer in Chinese and European populations. Then, we compared genetic risk and smoking as well as their interactions on lung cancer between two cohorts, including the China Kadoorie Biobank (CKB) and the UK Biobank (UKB). We also evaluated the absolute risk reduction over a 5-year period.</p>
RESULTS: Differences in compositions and association effects were observed between the Chinese-specific PRSs and European-specific PRSs, especially for smoking-related loci. The PRSs were consistently associated with lung cancer risk, but stronger associations were observed in smokers of the UKB [hazard ratio (HR) 1.26 vs 1.15, P = 0.028]. A significant interaction between genetic risk and smoking on lung cancer was observed in the UKB (RERI, 11.39 (95% CI, 7.01-17.94)], but not in the CKB. Obvious higher absolute risk was observed in nonsmokers of the CKB, and a greater absolute risk reduction was found in the UKB (10.95 vs 7.12 per 1000 person-years, P <0.001) by comparing heavy smokers with nonsmokers, especially for those at high genetic risk.</p>
CONCLUSIONS: Ethnic differences in genetic factors and the high incidence of lung cancer in nonsmokers of East Asian ethnicity were involved in the disparity of smoking-related risk of lung cancer.</p>
25 Authors
- Meng Zhu
- Jun Lv
- Yanqian Huang
- Hongxia Ma
- Ni Li
- Xiaoxia Wei
- Mengmeng Ji
- Zhimin Ma
- Ci Song
- Cheng Wang
- Juncheng Dai
- Fengwei Tan
- Yu Guo
- Robin Walters
- Iona Y Millwood
- Rayjean J Hung
- David C Christiani
- Canqing Yu
- Guangfu Jin
- Zhengming Chen
- Qingyi Wei
- Christopher I Amos
- Zhibin Hu
- Liming Li
- Hongbing Shen
1 Application
| Application ID | Title |
|---|---|
| 48700 | Polygenic risk scores for risk assessment of lung cancer in the UK Biobank and China Kadoorie Biobank |
Enabling scientific discoveries that improve human health