| Title: | Association between metabolic syndrome and risk of incident dementia in UK Biobank |
| Journal: | Alzheimer's & Dementia |
| Published: | 7 Sep 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37675869/ |
| DOI: | https://doi.org/10.1002/alz.13439 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.13439 |
Publication 9610
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Abstract
INTRODUCTION: The association between metabolic syndrome (MetS) and incident dementia remains inconclusive.</p>
METHODS: In 176,249 dementia-free UK Biobank participants aged ≥60 years at baseline, Cox proportional-hazards models were used to investigate the association between MetS and incident dementia. MetS was defined as the presence of ≥3 of the following: elevated waist circumference, triglycerides, blood pressure, blood glucose, and reduced high-density lipoprotein cholesterol.</p>
RESULTS: Over 15 years of follow-up (median = 12.3), 5255 participants developed dementia. MetS was associated with an increased risk of incident dementia (hazard ratio [HR]: 1.12, 95% confidence interval [CI]: 1.06, 1.18). The association remained consistent when restricting to longer follow-up intervals: >5 to 10 years (HR: 1.17, 95% CI: 1.07, 1.27) and >10 years (HR: 1.22, 95% CI: 1.12, 1.32). Stronger associations were observed in those with ≥4 MetS components and in apolipoprotein-E (APOE)-ε4 non-carriers.</p>
DISCUSSION: In this large population-based prospective cohort, MetS was associated with an increased risk of dementia.</p>
HIGHLIGHTS: MetS was associated with a 12% increased risk of incident all-cause dementia. Associations remained similar after restricting the analysis to those with longer follow-up. The presence of four or five MetS components was significantly associated with dementia. Stronger associations were observed in those with a low genetic risk for dementia.</p>
5 Authors
- Danial Qureshi
- Jennifer Collister
- Naomi E. Allen
- Elżbieta Kuźma
- Thomas Littlejohns
1 Application
| Application ID | Title |
|---|---|
| 33952 | Risk profiles for cancers; polygenic risk scores with and without non-genetic risk factors |
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