| Title: | Age at Onset of Heart Failure and Subsequent Risk of Dementia A Longitudinal Cohort Study |
| Journal: | JACC Heart Failure |
| Published: | 14 Sep 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37768248/ |
| DOI: | https://doi.org/10.1016/j.jchf.2023.08.006 |
Publication 9531
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: The average age at onset of heart failure (HF) shows a progressive decrease in recent years; however, the association between age at onset of HF and risk of subsequent dementia remains undetermined.</p>
OBJECTIVES: The study sought to examine whether younger onset age of HF is associated with a higher risk of incident dementia.</p>
METHODS: Individual-level data from the UK Biobank cohort study were analyzed in the present study. Cox regression models and the propensity score matching method were used to analyze the associations of HF and its onset age with subsequent all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VD).</p>
RESULTS: Compared with 442,791 participants without HF, those with HF had a higher risk of all-cause dementia (HR: 1.14). Among 14,413 participants with HF, multivariable-adjusted HRs for all-cause dementia, AD, and VD were 1.18, 1.64, and 1.27, respectively, per 10-year decrease in age at HF onset. The propensity score matching analyses found that the strength of association between HF and all-cause dementia increased with decreasing onset age of HF (≥75 years, HR: 1.05; 65-74 years, HR: 1.10; <65 years, HR: 1.67) after multivariable adjustment. Similarly, participants with onset age of HF <65 years had the greatest HRs for incident AD and VD, compared with their matched control subjects.</p>
CONCLUSIONS: Younger age at HF onset was associated with increased risk of dementia. Individuals with an onset age of HF before 65 years of age may represent a particularly vulnerable population for dementia irrespective of subtypes and need careful monitoring and timely intervention to attenuate subsequent risk of incident dementia.</p>
9 Authors
- Fanfan Zheng
- Jie Liang
- Chenglong Li
- Qian Ma
- Yang Pan
- Wenya Zhang
- Darui Gao
- Yongqian Wang
- Wuxiang Xie
1 Application
| Application ID | Title |
|---|---|
| 90492 | Identification of risk factors for major chronic diseases among older adults |
Enabling scientific discoveries that improve human health