| Title: | Pathways explaining racial/ethnic and socio-economic disparities in dementia incidence: the UK Biobank study |
| Journal: | Aging |
| Published: | 25 Sep 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37751591/ |
| DOI: | https://doi.org/10.18632/aging.205058 |
| URL: | https://www.aging-us.com/article/205058/pdf |
Publication 9476
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Abstract
BACKGROUND: Pathways explaining racial/ethnic disparities in dementia risk are under-evaluated.</p>
METHODS: We examine those disparities and their related pathways among UK Biobank study respondents (50-74 y, N = 323,483; 3.6% non-White minorities) using a series of Cox proportional hazards and generalized structural equations models (GSEM).</p>
RESULTS: After ≤15 years, 5,491 all-cause dementia cases were diagnosed. Racial minority status (RACE_ETHN, Non-White vs. White) increased dementia risk by 24% (HR = 1.24, 95% CI: 1.07-1.45, P = 0.005), an association attenuated by socio-economic status (SES), (HR = 1.12, 95% CI: 0.96-1.31). Total race-dementia effect was mediated through both SES and Life's Essential 8 lifestyle sub-score (LE8LIFESTYLE), combining diet, smoking, physical activity, and sleep factors. SES was inversely related to dementia risk (HR = 0.69, 95% CI: 0.67, 0.72, P < 0.001). Pathways explaining excess dementia risk among racial minorities included 'RACE_ETHN(-) → SES(-) → DEMENTIA', 'RACE_ETHN(-) → SES(-) → Poor cognitive performance, COGN(+) → DEMENTIA' and 'RACE_ETHN(-) → SES(+) → LE8LIFESTYLE(-) → DEMENTIA'.</p>
CONCLUSIONS: Pending future interventions, lifestyle factors including diet, smoking, physical activity, and sleep are crucial for reducing racial and socio-economic disparities in dementia.</p>
9 Authors
- May A Beydoun
- Hind A Beydoun
- Marie T Fanelli-Kuczmarski
- Jordan Weiss
- Michael F Georgescu
- Osorio Meirelles
- Donald M Lyall
- Michele K Evans
- Alan B Zonderman
1 Application
| Application ID | Title |
|---|---|
| 77963 | Dissecting racial/ethnic disparities in dementia traits through socio-economic, lifestyle, cardio-metabolic risk and infectious agents, with focus on Helicobacter pylori sero-positivity |
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