| Title: | Longitudinal associations of cardiovascular health and vascular events with incident dementia |
| Journal: | Stroke and Vascular Neurology |
| Published: | 12 Oct 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37827852/ |
| DOI: | https://doi.org/10.1136/svn-2023-002665 |
| URL: | https://svn.bmj.com/content/svnbmj/early/2023/10/12/svn-2023-002665.full.pdf |
Publication 9390
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Abstract
INTRODUCTION: Evidence supporting cardiovascular diseases could increase the risk of dementia remains fragmented. A comprehensive study to illuminate the distinctive associations across different dementia types is still lacking. This study is sought to: (1) determine the clinical validity of Framingham General Cardiovascular Risk Score (FGCRS) for dementia assessment and (2) examine the associations between cardiovascular diseases and the risk of dementia.</p>
METHODS: A total of 432 079 dementia-free individuals at baseline from UK Biobank were included. Multivariable Cox proportional hazard models were used to investigate the prospective associations for FGCRS and a series of cardiovascular diseases with all-cause dementia (ACD) and its major components, Alzheimer's disease (AD) and vascular dementia (VaD).</p>
RESULTS: During a median follow-up of 110.1 months, 4711 individuals were diagnosed with dementia. FGCRS was associated with increased risks across the dementia spectrum. In stratification analysis, high-risk groups have demonstrated the greatest dementia burdens, particularly to VaD. Over 74 traits, 9 adverse associations, such as chronic ischaemic heart disease (ACD: HR=1.354; AD: HR=1.269; VaD: HR=1.768), atrioventricular block (ACD: HR=1.562; AD: HR=1.556; VaD: HR=2.069), heart failure (ACD: HR=1.639; AD: HR=1.543; VaD: HR=2.141) and hypotension (ACD: HR=2.912; AD: HR=2.361; VaD: HR=3.315) were observed. Several distinctions were also found, with atrial fibrillation, cerebral infarction, and haemorrhage only associated with greater risks of ACD and VaD.</p>
DISCUSSION: By identifying distinctive associations between cardiovascular diseases and dementia, this study has established a comprehensive 'mapping' that may untangle the long-standing discrepancy. FGCRS has demonstrated its predictivity beyond cardiovascular diseases burdens, suggesting potential opportunities for implantation.</p>
15 Authors
- Ya-Nan Ou
- Kevin Kuo
- Liu Yang
- Ya-Ru Zhang
- Shu-Yi Huang
- Shi-Dong Chen
- Yue-Ting Deng
- Yu Guo
- Rui-Qi Zhang
- Bang-Sheng Wu
- Lan Tan
- Qiang Dong
- Jian-Feng Feng
- Wei Cheng
- Jin-Tai Yu
1 Application
| Application ID | Title |
|---|---|
| 19542 | Identifying multi-level biomarkers and disease mechanisms for major mental disorders |
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