| Title: | Total and regional fat-to-muscle mass ratio and risk of incident breast and ovarian cancers |
| Journal: | Journal of Public Health |
| Published: | 19 Oct 2023 |
| DOI: | https://doi.org/10.1007/s10389-023-02116-8 |
Publication 9357
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Abstract
BackgroundThe fat-to-muscle mass ratio (FMR) has been proposed as a meaningful indicator of risk of obesity. This study investigated the associations between total and regional FMR and incident breast/ovarian cancer.MethodsA total of 256,390 participants (women, mean age 56.35 ± 7.98 years old) from the UK Biobank were enrolled. The association was estimated by Cox proportional hazard models.ResultsDuring a median 8.77 years follow-up, 6976 cases of breast cancer and 798 cases of ovarian cancer were recruited. Significant associations were found between total, leg, and trunk FMR and breast cancer risk, trunk FMR, and ovarian cancer risk after adjustment for BMI and other confounders. There was a dose-response relationship between trunk FMR and the risk of breast/ovarian cancer (Pfor trend <0.05). Compared to the lowest quartile, the highest quartile of FMR in the trunk increased the risk of breast cancer by 19% and risk of ovarian cancer by 37%. Stratified analysis showed the associations of total and regional FMR with incident breast cancer, arm and leg FMR with incident ovarian cancer were more pronounced among the normal weight population (BMI <25 kg/m2) than in overweight/obese (BMI ≥25 kg/m2, Pinteraction <0.05) women.ConclusionsThe correlations between total, leg, and trunk FMR and breast cancer risk, trunk FMR, and ovarian cancer risk were independent of BMI. The association between trunk and leg FMR and breast cancer risk increased with the increase of FMR quartile and was significantly stronger among women whose BMI was below 25 kg/m2.</p>
5 Authors
- Hongyang Li
- Ninghao Huang
- Wenxiu Wang
- Tao Huang
- Linlin Wang
Enabling scientific discoveries that improve human health