| Title: | A Population-Based Outcome-Wide Association Study of the Comorbidities and Sequelae Following COVID-19 Infection |
| Journal: | Journal of Epidemiology and Global Health |
| Published: | 27 Oct 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37889436/ |
| DOI: | https://doi.org/10.1007/s44197-023-00161-w |
| URL: | https://link.springer.com/content/pdf/10.1007/s44197-023-00161-w.pdf |
Publication 9322
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Abstract
BackgroundImmense attention has been given to the outcome of COVID-19 infection. However, comprehensive studies based on large populational cohort with long-term follow-up are still lacking. This study aimed to investigate the risk of various short-term comorbidities (within one month) and long-term sequelae (above one month) after COVID-19 infection.MethodsIn this large prospective cohort study with 14 months follow-up information based on UK biobank, we included 16,776 COVID-19-positive participants and 58,281 COVID-19-negative participants matched for comparison. The risk of each comorbidity and sequela was evaluated by multivariable logistic regression analysis and presented as hazard ratio (HR) and 95% confidence interval (95% CI).ResultsCOVID-19-positive individuals had a higher risk of 47 types of comorbidities within one month following COVID-19 infection, especially those who were older, male, overweight/obese, ever-smoked, with more pre-existing comorbidities and hospitalized. About 70.37% of COVID-19 patients with comorbidities had more than one co-occurring comorbidities. Additionally, only 6 high-risk sequelae were observed after one month of COVID-19 infection, and the incidence was relatively low (< 1%).ConclusionIn addition to long-term sequelae following COVID-19 infection, plenty of comorbidities were observed, especially in patients with older age, male gender, overweight/obese, more pre-existing comorbidities and severe COVID-19, indicating that more attention should be given to these susceptible persons within this period.</p>
21 Authors
- Yuyang Zhang
- Junhong Li
- Lan Feng
- Yaxin Luo
- Wendu Pang
- Ke Qiu
- Minzi Mao
- Yao Song
- Danni Cheng
- Yufang Rao
- Xinyi Wang
- Yao Hu
- Zhiye Ying
- Xiaobin Pu
- Shuyan Lin
- Shaohui Huang
- Geoffrey Liu
- Wei Zhang
- Wei Xu
- Yu Zhao
- Jianjun Ren
Enabling scientific discoveries that improve human health