| Title: | Relationship between Serum 25(OH)D and Depression: Causal Evidence from a Bi-Directional Mendelian Randomization Study |
| Journal: | Nutrients |
| Published: | 30 Dec 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33396887/ |
| DOI: | https://doi.org/10.3390/nu13010109 |
| URL: | https://www.mdpi.com/2072-6643/13/1/109/pdf |
Publication 9320
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Abstract
The relationship between depression and vitamin D deficiency is complex, with evidence mostly from studies affected by confounding and reverse causality. We examined the causality and direction of the relationship between 25-hydroxyvitamin D (25(OH)D) and depression in bi-directional Mendelian randomization (MR) analyses using information from up to 307,618 white British participants from the UK Biobank and summary results from the SUNLIGHT (n = 79,366) and Psychiatric Genomics consortia (PGC 113,154 cases and 218,523 controls). In observational analysis, the odds of depression decreased with higher 25(OH)D concentrations (adjusted odds ratio (OR) per 50% increase 0.95, 95%CI 0.94-0.96). In MR inverse variance weighted (IVW) using the UK Biobank, there was no association between genetically determined serum 25(OH)D and depression (OR per 50% higher 0.97, 95%CI 0.90-1.05) with consistent null association across all MR approaches and in data from PGC consortium. In contrast, genetic liability to depression was associated with lower 25(OH)D concentrations (MR IVW -3.26%, -4.94%--1.55%), with the estimates remaining generally consistent after meta-analysing with the consortia. In conclusion, we found genetic evidence for a causal effect of depression on lower 25(OH)D concentrations, however we could not confirm a beneficial effect of nutritional vitamin D status on depression risk.</p>
3 Authors
- Anwar Mulugeta
- Amanda Lumsden
- Elina Hyppönen
1 Application
| Application ID | Title |
|---|---|
| 10171 | Nutritional and lifestyle influences on neurocognitive and mental health: genetic epidemiological study on causal effects, mediating pathways and gene-environment interaction |
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