| Title: | Associations between actigraphy-measured sleep duration, continuity, and timing with mortality in the UK Biobank |
| Journal: | Sleep |
| Published: | 8 Dec 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38066693/ |
| DOI: | https://doi.org/10.1093/sleep/zsad312 |
| URL: | https://academic.oup.com/sleep/advance-article-pdf/doi/10.1093/sleep/zsad312/54143236/zsad312.pdf |
Publication 9201
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Abstract
STUDY OBJECTIVES: To examine the associations between sleep duration, continuity, timing, and mortality using actigraphy among adults.</p>
METHODS: Data were from a cohort of 88,282 adults (40-69yrs) in UK Biobank that wore a wrist-worn triaxial accelerometer for 7-days. Actigraphy data were processed to generate estimates of sleep duration and other sleep characteristics including wake after sleep onset (WASO), number of 5-min awakenings, and midpoint for sleep onset/wake-up and the least active 5 hours (L5). Data were linked to mortality outcomes with follow-up to 10/31/21. We implemented Cox models (Hazard ratio, confidence intervals [HR, 95% CI]) to quantify sleep associations with mortality. Models were adjusted for demographics, lifestyle factors, and medical conditions.</p>
RESULTS: Over an average of 6.8 years 2,973 deaths occurred (1,700 cancer, 586 CVD deaths). Overall sleep duration was significantly associated with risk for all-cause (p<0.01), cancer (p<0.01), and CVD (p=0.03) mortality. For example, when compared to sleep durations of 7.0 hrs/d, durations of 5 hrs/d were associated with a 29% higher risk for all-cause mortality (HR: 1.29 [1.09, 1.52]). WASO and number of awakenings were not associated with mortality. Individuals with L5 early or late midpoints (<2:30 or ≥3:30) had a ~20% higher risk for all-cause mortality, compared to those with intermediate L5 midpoints (3:00-3:29; p≤0.01; e.g., HR≥3:30: 1.19 [1.07, 1.32]).</p>
CONCLUSIONS: Shorter sleep duration and both early and late sleep timing were associated with a higher mortality risk. These findings reinforce the importance of public health efforts to promote healthy sleep patterns in adults.</p>
12 Authors
- Pedro F Saint-Maurice
- Joshua R Freeman
- Daniel Russ
- Jonas S Almeida
- Marissa M Shams-White
- Shreya Patel
- Dana L Wolff-Hughes
- Eleanor L Watts
- Erikka Loftfield
- Hyokyoung G Hong
- Steven C Moore
- Charles E Matthews
1 Application
| Application ID | Title |
|---|---|
| 43456 | Association of physical activity, fitness, and obesity with cancer incidence and mortality. |
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