| Title: | A multidimensional social risk atlas of depression and anxiety: An observational and genome-wide environmental interaction study |
| Journal: | Journal of Global Health |
| Published: | 8 Dec 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38063329/ |
| DOI: | https://doi.org/10.7189/jogh.13.04146 |
| URL: | https://jogh.org/wp-content/uploads/2023/12/jogh-13-04146.pdf |
| Citations: | 1 (1 in last 2 years) as of 8 Aug 2024 |
Publication 9198
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Abstract
Background: Mental disorders are largely socially determined, yet the combined impact of multidimensional social factors on the two most common mental disorders, depression and anxiety, remains unclear.</p>
Methods: We constructed a polysocial risk score (PsRS), a multidimensional social risk indicator including components from three domains: socioeconomic status, neighborhood and living environment and psychosocial factors. Supported by the UK Biobank cohort, we randomly divided 110 332 participants into the discovery cohort (60%; n = 66 200) and the replication cohort (40%; n = 44 134). We tested the associations between 13 single social factors with Patient Health Questionnaire (PHQ) score, Generalized Anxiety Disorder Scale (GAD) score and self-reported depression and anxiety. The significant social factors were used to calculate PsRS for each mental disorder by considering weights from the multivariable linear model. Generalized linear models were applied to explore the association between PsRS and depression and anxiety. Genome-wide environmental interaction study (GWEIS) was further performed to test the effect of interactions between PsRS and SNPs on the risk of mental phenotypes.</p>
Results: In the discovery cohort, PsRS was positively associated with PHQ score (β = 0.37; 95% CI = 0.35-0.38), GAD score (β = 0.27; 95% CI = 0.25-0.28), risk of self-reported depression (OR = 1.29; 95% CI = 1.28-1.31) and anxiety (OR = 1.19; 95% CI = 1.19-1.23). Similar results were observed in the replication cohort. Emotional stress, lack of social support and low household income were significantly associated with the development of depression and anxiety. GWEIS identified multiple candidate loci for PHQ score, such as rs149137169 (ST18) (Pdiscovery = 1.08 × 10-8, Preplication = 3.25 × 10-6) and rs3759812 (MYO9A) (Pdiscovery = 3.87 × 10-9, Preplication = 6.21 × 10-5). Additionally, seven loci were detected for GAD score, such as rs114006170 (TMPRSS11D) (Pdiscovery = 1.14 × 10-9, Preplication = 7.36 × 10-5) and rs77927903 (PIP4K2A) (Pdiscovery = 2.40 × 10-9, Preplication = 0.002).</p>
Conclusions: Our findings reveal the positive effects of multidimensional social factors on the risk of depression and anxiety. It is important to address key social disadvantage in mental health promotion and treatment.</p>
17 Authors
- Chuyu Pan
- Li Liu
- Shiqiang Cheng
- Xuena Yang
- Peilin Meng
- Na Zhang
- Dan He
- Yujing Chen
- Chun'e Li
- Huijie Zhang
- Jingxi Zhang
- Zhen Zhang
- Bolun Cheng
- Yan Wen
- Yumeng Jia
- Huan Liu
- Feng Zhang
1 Application
| Application ID | Title |
|---|---|
| 46478 | Multi-omics integrative studies of common psychiatric disorders and skeletal disorders |
Enabling scientific discoveries that improve human health