| Title: | Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease |
| Journal: | Diabetologia |
| Published: | 12 Dec 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38085289/ |
| DOI: | https://doi.org/10.1007/s00125-023-06058-4 |
| URL: | https://link.springer.com/content/pdf/10.1007/s00125-023-06058-4.pdf |
Publication 9182
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Abstract
Aims/hypothesisChildhood overweight increases the risk of type 2 diabetes and cardiovascular disease in adulthood. However, the impact of childhood leanness on adult obesity and disease risk has been overlooked. We examined the independent and combined influences of child and adult body size on the risk of type 2 diabetes and cardiovascular disease.MethodsData from the UK Biobank on 364,695 individuals of European ancestry and free of type 2 diabetes and cardiovascular disease were divided into nine categories based on their self-reported body size at age 10 and measured BMI in adulthood. After a median follow-up of 12.8 years, 33,460 individuals had developed type 2 diabetes and/or cardiovascular disease. We used Cox regression models to assess the associations of body size categories with disease incidence.ResultsIndividuals with low body size in childhood and high body size in adulthood had the highest risk of type 2 diabetes (HR 4.73; 95% CI 4.50, 4.99), compared to those with average body size in both childhood and adulthood. This was significantly higher than the risk in those with high body size in both childhood and adulthood (HR 4.05; 95% CI 3.84, 4.26). By contrast, cardiovascular disease risk was determined by adult body size, irrespective of childhood body size.Conclusions/interpretationLow body size in childhood exacerbates the risk of type 2 diabetes associated with adult obesity but not the risk of cardiovascular disease. Thus, promoting healthy weight management from childhood to adulthood, among lean children, is crucial.Graphical Abstract</p>
5 Authors
- Germán D. Carrasquilla
- Lars Ängquist
- Thorkild I. A. Sørensen
- Tuomas O. Kilpeläinen
- Ruth J. F. Loos
1 Application
| Application ID | Title |
|---|---|
| 32683 | Combined effect of the genetic and lifestyle determinants of metabolic syndrome on cardiometabolic risk |
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