| Title: | DeepGraFT: A novel semantic segmentation auxiliary ROI-based deep learning framework for effective fundus tessellation classification |
| Journal: | Computers in Biology and Medicine |
| Published: | 23 Dec 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38159401/ |
| DOI: | https://doi.org/10.1016/j.compbiomed.2023.107881 |
Publication 9129
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Abstract
Fundus tessellation (FT) is a prevalent clinical feature associated with myopia and has implications in the development of myopic maculopathy, which causes irreversible visual impairment. Accurate classification of FT in color fundus photo can help predict the disease progression and prognosis. However, the lack of precise detection and classification tools has created an unmet medical need, underscoring the importance of exploring the clinical utility of FT. Thus, to address this gap, we introduce an automatic FT grading system (called DeepGraFT) using classification-and-segmentation co-decision models by deep learning. ConvNeXt, utilizing transfer learning from pretrained ImageNet weights, was employed for the classification algorithm, aligning with a region of interest based on the ETDRS grading system to boost performance. A segmentation model was developed to detect FT exits, complementing the classification for improved grading accuracy. The training set of DeepGraFT was from our in-house cohort (MAGIC), and the validation sets consisted of the rest part of in-house cohort and an independent public cohort (UK Biobank). DeepGraFT demonstrated a high performance in the training stage and achieved an impressive accuracy in validation phase (in-house cohort: 86.85 %; public cohort: 81.50 %). Furthermore, our findings demonstrated that DeepGraFT surpasses machine learning-based classification models in FT classification, achieving a 5.57 % increase in accuracy. Ablation analysis revealed that the introduced modules significantly enhanced classification effectiveness and elevated accuracy from 79.85 % to 86.85 %. Further analysis using the results provided by DeepGraFT unveiled a significant negative association between FT and spherical equivalent (SE) in the UK Biobank cohort. In conclusion, DeepGraFT accentuates potential benefits of the deep learning model in automating the grading of FT and allows for potential utility as a clinical-decision support tool for predicting progression of pathological myopia.</p>
16 Authors
- Yinghao Yao
- Jiaying Yang
- Haojun Sun
- Hengte Kong
- Sheng Wang
- Ke Xu
- Wei Dai
- Siyi Jiang
- QingShi Bai
- Shilai Xing
- Jian Yuan
- Xinting Liu
- Fan Lu
- Zhenhui Chen
- Jia Qu
- Jianzhong Su
1 Application
| Application ID | Title |
|---|---|
| 45270 | An artificial intelligence algorithm based on deep learning and molecular diagnosis for identifying ocular diseases. |
Enabling scientific discoveries that improve human health