| Title: | Higher risk of osteoporosis in adult-onset asthma than childhood-onset asthma: from genetic and prospective evidence |
| Journal: | Osteoporosis International |
| Published: | 23 Dec 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38141141/ |
| DOI: | https://doi.org/10.1007/s00198-023-07004-1 |
Publication 9078
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Abstract
Both COA and AOA have a genetically causal effect on osteoporosis. COA and AOA were independently associated with incident osteoporosis, and the risk was greatly higher in AOA. Besides corticosteroids, the increased risk of osteoporosis among asthma patients should be attributed to genetic susceptibility and other asthma medications.Purpose/IntroductionChildhood-onset asthma (COA) differs with adult-onset asthma (AOA) on genetic susceptibility, severity, and co-morbidities. Whether COA or AOA is independently associated with osteoporosis is unexplored. We aimed to determine the effects of COA and AOA on osteoporosis at genetic and individual level.MethodsWe used two-sample Mendelian randomization analysis to explore the causal effects of COA and AOA on osteoporosis. In the UK Biobank cohort, we included 478,289 osteoporosis-free participants at baseline (2006-2010). Participants were classified as non-asthma, COA, and AOA at recruitment. Multivariate Cox regression analysis was used to evaluate the effects of COA, AOA, and multiple asthma medications on incident osteoporosis risk.ResultsCOA and AOA were causally related to osteoporosis, with odds ratio of 1.007 (95% confidence interval (CI), 1.0003-1.0132) and 1.012 (95% CI, 1.002-1.023), respectively. Multivariate Cox regression analysis suggested that COA (hazard ratio (HR), 1.46; 95% CI, 1.32-1.61) and AOA (HR, 1.70; 95% CI, 1.61-1.80) were independently associated with incident osteoporosis, and the risk was greatly higher in AOA (HR, 1.51; 95% CI, 1.34-1.70). In addition to corticosteroids, monotherapy with leukotriene modifiers (HR, 1.70; 95% CI, 1.20-2.42), long-acting beta agonists (HR, 1.49; 95% CI, 1.18-1.87), and short-acting beta agonists (HR, 1.72; 95% CI1.01-2.93) were independently associated with a higher risk of osteoporosis.ConclusionsBoth COA and AOA have a genetically causal effect on osteoporosis, and the risk of osteoporosis is greatly higher in AOA. Besides corticosteroids, the increased risk of osteoporosis among asthma patients should be attributed to genetic susceptibility and other asthma medications.</p>
8 Authors
- Weizhong Ding
- Yong Huang
- Guanghui Li
- Yimin Dong
- Xiaochen Li
- Minglong Wu
- Kehan Song
- Feng Li
1 Application
| Application ID | Title |
|---|---|
| 81888 | Investigating phenotypic and genotypic characteristics that influence degenerative bone disease |
Enabling scientific discoveries that improve human health