| Title: | Visceral adiposity associated with incidence and development trajectory of cardiometabolic diseases: A prospective cohort study |
| Journal: | Nutrition Metabolism and Cardiovascular Diseases |
| Published: | 30 Dec 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38331642/ |
| DOI: | https://doi.org/10.1016/j.numecd.2023.12.024 |
Publication 9059
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Abstract
BACKGROUND AND AIMS: There is a lack of literature concerning the effects of visceral adipose on the development of first cardiometabolic disease (FCMD) and its subsequent progression to cardiometabolic multimorbidity (CMM) and mortality.</p>
METHODS AND RESULTS: 423,934 participants from the UK Biobank with different baseline disease conditions were included in the analysis. CMM was defined as the simultaneous presence of coronary heart disease, T2D, and stroke. Visceral adiposity was estimated by calculating the visceral adiposity index (VAI). Multistate models were used to assess the effect of visceral adiposity on the development of CMM. During a median follow-up of 13.5 years, 50,589 patients had at least one CMD, 6131 were diagnosed with CMM, whereas 24,634 patients died. We observed distinct roles of VAI with respect to different disease transitions of CMM. HRs (95 % CIs) of high VAI were 2.35 (2.29-2.42) and 1.64 (1.50-1.79) for transitions from healthy to FCMD and from FCMD to CMM, and 0.97 (0.93-1.02) for all-cause mortality risk from healthy, FCMD and CMM, respectively.</p>
CONCLUSIONS: Our study provides the first evidence that visceral adipose may contribute to the development of FCMD and CMM in healthy participants. However, visceral adipose may confer resistance to all-cause mortality in participants with existing CMD or CMM. A better understanding of the relationship between visceral adipose and CMM can focalize further investigations on patients with CMD with high levels of visceral fat and help take targeted preventive measures to reduce the medical burden on individual patients and society.</p>
13 Authors
- Qida He
- Yu Wang
- Zhaolong Feng
- Jiadong Chu
- Tongxing Li
- Wei Hu
- Xuanli Chen
- Qiang Han
- Na Sun
- Siyuan Liu
- Mengtong Sun
- Hongpeng Sun
- Yueping Shen
1 Application
| Application ID | Title |
|---|---|
| 68136 | Prediction of the risk of morbidity, recurrence and mortality of cardiovascular diseases and cancer: the effect of environmental, clinical and genetic factors |
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