| Title: | Social isolation, loneliness and subsequent risk of major adverse cardiovascular events among individuals with type 2 diabetes mellitus |
| Journal: | General Psychiatry |
| Published: | 27 Dec 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38170087/ |
| DOI: | https://doi.org/10.1136/gpsych-2023-101153 |
| URL: | https://gpsych.bmj.com/content/gpsych/36/6/e101153.full.pdf |
Publication 9051
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Abstract
Background: Individuals with type 2 diabetes mellitus (T2DM) are more vulnerable to social disconnection compared with the general population; however, there are few relevant studies investigating this issue.</p>
Aims: To investigate whether social isolation or loneliness may be associated with subsequent risk of developing major adverse cardiovascular events, whether these associations vary according to fatal and non-fatal outcomes and how behavioural, psychological and physiological factors mediate these associations.</p>
Methods: This longitudinal analysis included data from 19 360 individuals with T2DM at baseline (2006-2010) from the UK Biobank. Social isolation and loneliness were measured using self-report questionnaires. The study outcomes included the first events of myocardial infarction (MI) or stroke (n=2273) and all-cause (n=2820) or cardiovascular disease-related mortality through linked hospital data or death registries.</p>
Results: Over a median follow-up of 12.4 years (interquartile range (IQR): 11.6-13.3 years), participants who were more socially isolated (most social isolation vs least social isolation) experienced increased risks for all-cause (hazard ratio (HR) : 1.33, 95% confidence interval (CI): 1.19 to 1.47) and cardiovascular disease (HR: 1.36, 95% CI: 1.17 to 1.59) mortality but not first MI or stroke. Loneliness (yes vs no) was associated with a greater risk for a composite of incident MI or stroke (HR: 1.37, 95% CI: 1.19 to 1.57) but not mortality. Social isolation was associated with fatal MI and stroke, whereas loneliness was associated with non-fatal MI and stroke. The significant associations of social isolation and loneliness with outcomes were mainly mediated by behavioural factors (mediating proportion: 17.8%-28.2% and 17.6%-17.8%, respectively).</p>
Conclusions: Among individuals with T2DM, social isolation and loneliness are associated with a greater risk of developing major adverse cardiovascular events, with differences in both risks stratified according to fatal and non-fatal events and underlying mediating factors.</p>
10 Authors
- Yannis Yan Liang
- Yilin Chen
- Hongliang Feng
- Huachen Xue
- Yu Nie
- Qi-Yong H Ai
- Jiacheng Ma
- Lulu Yang
- Jihui Zhang
- Sizhi Ai
1 Application
| Application ID | Title |
|---|---|
| 59117 | The association of vascular and systemic inflammation with cerebrovascular diseases and its related outcomes |
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