| Title: | Establishing the variation of blood metrics within UK Biobank to inform cell therapy manufacturing processes |
| Journal: | Regenerative Medicine |
| Published: | 13 Nov 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/31718498/ |
| DOI: | https://doi.org/10.2217/rme-2018-0168 |
Publication 9049
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Abstract
Aim: Understanding blood component variation as a function of healthy population metrics is necessary to inform biomanufacturing process design. Methods: UK Biobank metrics were examined for variation in white blood cell count as an analog to potential manufacturing starting material input. Results: White blood cell count variation of four orders of magnitude (6.65 × 109 cells/l) was found. Variation increased with age, increased with weight up to 80 kg then decreased. Health state showed a greater absolute number of participants with elevated count. Female range was greater than male. Cell count/distributions were different between centers. Conclusion: This variation and range of process input signals a requirement for new strategies for manufacturing process design and control.</p>
14 Keywords
- Age Factors
- Aged
- Aged, 80 and over
- Biological Specimen Banks
- Body Weight
- Cell- and Tissue-Based Therapy
- Diet
- Exercise
- Female
- Humans
- Leukocytes
- Male
- Middle Aged
- United Kingdom
3 Authors
- Jamie Thurman-Newell
- Jon Petzing
- David J Williams
1 Application
| Application ID | Title |
|---|---|
| 4047 | Quantification of Variation in Blood |
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