| Title: | Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications |
| Journal: | European Journal of Epidemiology |
| Published: | 2 Jan 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38165527/ |
| DOI: | https://doi.org/10.1007/s10654-023-01088-z |
| URL: | https://link.springer.com/content/pdf/10.1007/s10654-023-01088-z.pdf |
Publication 9011
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Abstract
Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50-64 years. The results were confirmed using 2-sample Mendelian randomization. Lower lung function and emphysema were associated with more atherosclerosis, but these relationships were attenuated after adjustment for cardiovascular risk factors. Lung function was not associated with coronary atherosclerosis in 14,524 never-smokers. No potentially causal effect of lung function on atherosclerosis, or vice versa, was found in the 2-sample Mendelian randomization analysis. Here we show that reduced lung function and atherosclerosis are correlated in the population, but probably not causally related. Assessing lung function in addition to conventional cardiovascular risk factors to gauge risk of subclinical atherosclerosis is probably not meaningful, but low lung function found by chance should alert for atherosclerosis.</p>
44 Authors
- Gunnar Engström
- Erik Lampa
- Koen Dekkers
- Yi-Ting Lin
- Kristin Ahlm
- Håkan Ahlström
- Joakim Alfredsson
- Göran Bergström
- Anders Blomberg
- John Brandberg
- Kenneth Caidahl
- Kerstin Cederlund
- Olov Duvernoy
- Jan E. Engvall
- Maria J. Eriksson
- Tove Fall
- Bruna Gigante
- Anders Gummesson
- Emil Hagström
- Viktor Hamrefors
- Jan Hedner
- Magnus Janzon
- Tomas Jernberg
- Linda Johnson
- Lars Lind
- Eva Lindberg
- Maria Mannila
- Ulf Nilsson
- Anders Persson
- Hans Lennart Persson
- Margaretha Persson
- Anna Ramnemark
- Annika Rosengren
- Caroline Schmidt
- Linn Skoglund Larsson
- C. Magnus Sköld
- Eva Swahn
- Stefan Söderberg
- Kjell Torén
- Anders Waldenström
- Per Wollmer
- Suneela Zaigham
- Carl Johan Östgren
- Johan Sundström
1 Application
| Application ID | Title |
|---|---|
| 52678 | Causal associations of novel and established risk factors with type 2 diabetes, kidney disease, lung disease and cardiovascular disease in UK Biobank |
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