| Title: | Genetic risk score for Alzheimer's disease predicts brain volume differences in mid and late life in UK biobank participants |
| Journal: | Alzheimer's & Dementia |
| Published: | 6 Jan 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38183377/ |
| DOI: | https://doi.org/10.1002/alz.13610 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.13610 |
Publication 8989
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Abstract
INTRODUCTION: We estimated the ages when associations between Alzheimer's disease (AD) genes and brain volumes begin among middle-aged and older adults.</p>
METHODS: Among 45,616 dementia-free participants aged 45-80, linear regressions tested whether genetic risk score for AD (AD-GRS) had age-dependent associations with 38 regional brain magnetic resonance imaging volumes. Models were adjusted for sex, assessment center, genetic ancestry, and intracranial volume.</p>
RESULTS: AD-GRS modified the estimated effect of age (per decade) on the amygdala (-0.41 mm3 [-0.42, -0.40]); hippocampus (-0.45 mm3 [-0.45, -0.44]), nucleus accumbens (-0.55 mm3 [-0.56, -0.54]), thalamus (-0.38 mm3 [-0.39, -0.37]), and medial orbitofrontal cortex (-0.23 mm3 [-0.24, -0.22]). Trends began by age 45 for the nucleus accumbens and thalamus, 48 for the hippocampus, 51 for the amygdala, and 53 for the medial orbitofrontal cortex. An AD-GRS excluding apolipoprotein E (APOE) was additionally associated with entorhinal and middle temporal cortices.</p>
DISCUSSION: APOE and other genes that increase AD risk predict lower hippocampal and other brain volumes by middle age.</p>
10 Authors
- Peter T. Buto
- Jingxuan Wang
- Renaud La Joie
- Scott C. Zimmerman
- M. Maria Glymour
- Sarah F. Ackley
- Thomas J. Hoffmann
- Kristine Yaffe
- Adina Zeki Al Hazzouri
- Willa D. Brenowitz
1 Application
| Application ID | Title |
|---|---|
| 78748 | Tools for evaluating bias in ADRD research |
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