| Title: | Generalized Analysis of Open Genetic Databases Reveals New Associations with Migraine |
| Journal: | Current Pharmacogenomics and Personalized Medicine |
| Published: | 12 Jan 2024 |
| DOI: | https://doi.org/10.2174/0118756921286656231219095417 |
Publication 8950
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Abstract
background: Migraine is one of the most common diseases that significantly impairs the quality of life. This condition has a pronounced genetic component. Genes responsible for the development of monogenic forms of hemiplegic migraine have already been identified, and the search for genetic associations with common migraine and its subtypes continues. objective: The aim of this study was to identify new potential genetic markers of migraine by analyzing available open genetic databases. method: : ClinVar, GWAS Catalog, UK Biobank and FinnGen databases were included in the analysis. The keyword "migraine" was used. Genetic variants with clinical annotations "pathogenic" and "likely pathogenic", or meeting association significance level of p ≤ 5×10-8 were chosen. result: A total of 112 genetic variants associated with migraine were identified. After comparing these polymorphisms with those known from previous migraine studies, it was found that 45 genetic variants were identified for the first time. conclusion: These variants belong to various functional groups, including ion channels, enzymes, receptors, and regulatory proteins, confirming the current understanding of the polygenic nature of migraine. The search for new genetic associations with migraine can contribute to a better understanding of its pathogenesis and open new possibilities for diagnosis and the development of more effective treatment strategies for this condition. </p>
2 Authors
- Aliya Yakubova
- Albert A. Rizvanov
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