| Title: | Association of Lipoprotein(a) with arterial stiffness: A Mendelian randomization study |
| Journal: | European Journal of Clinical Investigation |
| Published: | 18 Jan 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38239089/ |
| DOI: | https://doi.org/10.1111/eci.14168 |
Publication 8921
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Abstract
BACKGROUND: In this study we used Mendelian randomization (MR) to investigate the potential causal association of lipoprotein (a) [Lp(a)] levels with pulse wave velocity (PWV).</p>
METHODS: Genetic variants associated with Lp(a) were retrieved from the UK Biobank GWAS (N = 290,497). A non- overlapping GWAS based on a European cohort (N = 7,000) was used to obtain genetic associations with PWV (outcome) and utilized two different measures for the same trait, brachial-ankle (baPWV) and carotid-femoral (cfPWV) PWV. We applied a two-sample MR using the inverse variance weighting method (IVW) and a series of sensitivity analyses for 170 SNPs that were selected as instrumental variables (IVs).</p>
RESULTS: Our analyses do not support a causal association between Lp(a) and PWV for neither measurement [βiwv (baPWV) = -.0005, p = .8 and βiwv (cfPWV) = -.006, p = .16]. The above findings were consistent across sensitivity analyses including weighted median, mode-based estimation, MR-Egger regression and MR-PRESSO.</p>
CONCLUSION: We did not find evidence indicating that Lp(a) is causally associated with PWV, the gold standard marker of arterial stiffness.</p>
9 Authors
- Alexandros Simistiras
- Georgios Georgiopoulos
- Dimitrios Delialis
- Georgios Mavraganis
- Ermioni Oikonomou
- Eleni Maneta
- Christos Loutos
- Evangelos Evangelou
- Kimon Stamatelopoulos
1 Application
| Application ID | Title |
|---|---|
| 13375 | Genome-wide association study of alcohol intake and tobacco smoking. |
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