| Title: | Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease |
| Journal: | Nature Communications |
| Published: | 18 Jan 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38238335/ |
| DOI: | https://doi.org/10.1038/s41467-024-44841-y |
| URL: | https://www.nature.com/articles/s41467-024-44841-y.pdf |
| Citations: | 3 (3 in last 2 years) as of 8 Aug 2024 |
Publication 8919
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Abstract
This work aims to investigate how smoking exerts effect on the development of inflammatory bowel disease (IBD). A prospective cohort study and a Mendelian randomization study are first conducted to evaluate the association between smoking behaviors, smoking-related DNA methylation and the risks of Crohn's disease (CD) and ulcerative colitis (UC). We then perform both genome-wide methylation analysis and co-localization analysis to validate the observed associations. Compared to never smoking, current and previous smoking habits are associated with increased CD (P = 7.09 × 10−10) and UC (P < 2 × 10−16) risk, respectively. DNA methylation alteration at cg17742416 [DNMT3A] is linked to both CD (P = 7.30 × 10−8) and UC (P = 1.04 × 10−4) risk, while cg03599224 [LTA/TNF] is associated with CD risk (P = 1.91 × 10−6), and cg14647125 [AHRR] and cg23916896 [AHRR] are linked to UC risk (P = 0.001 and 0.002, respectively). Our study identifies biological mechanisms and pathways involved in the effects of smoking on the pathogenesis of IBD.</p>
17 Authors
- Han Zhang
- Rahul Kalla
- Jie Chen
- Jianhui Zhao
- Xuan Zhou
- Alex Adams
- Alexandra Noble
- Nicholas T. Ventham
- Judith Wellens
- Gwo-Tzer Ho
- Malcolm G. Dunlop
- Jan Krzysztof Nowak
- Yuan Ding
- Zhanju Liu
- Jack Satsangi
- Evropi Theodoratou
- Xue Li
1 Application
| Application ID | Title |
|---|---|
| 73595 | Comorbidities and Systemic Inflammation Related Outcomes of Inflammatory Bowel Disease |
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