| Title: | Causal association between snoring and stroke: a Mendelian randomization study in a Chinese population |
| Journal: | The Lancet Regional Health - Western Pacific |
| Published: | 23 Jan 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38304719/ |
| DOI: | https://doi.org/10.1016/j.lanwpc.2023.101001 |
| URL: | http://www.thelancet.com/article/S266660652300319X/pdf |
Publication 8905
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Abstract
Background: Previous observational studies established a positive relationship between snoring and stroke. We aimed to investigate the causal effect of snoring on stroke.</p>
Methods: Based on 82,339 unrelated individuals with qualified genotyping data of Asian descent from the China Kadoorie Biobank (CKB), we conducted a Mendelian randomization (MR) analysis of snoring and stroke. Genetic variants identified in the genome-wide association analysis (GWAS) of snoring in CKB and UK Biobank (UKB) were selected for constructing genetic risk scores (GRS). A two-stage method was applied to estimate the associations of the genetically predicted snoring with stroke and its subtypes. Besides, MR analysis among the non-obese group (body mass index, BMI <24.0 kg/m2), as well as multivariable MR (MVMR), were performed to control for potential pleiotropy from BMI. In addition, the inverse-variance weighted (IVW) method was applied to estimate the causal association with genetic variants identified in CKB GWAS.</p>
Findings: Positive associations were found between snoring and total stroke, hemorrhagic stroke (HS), and ischemic stroke (IS). With GRS of CKB, the corresponding HRs (95% CIs) were 1.56 (1.15, 2.12), 1.50 (0.84, 2.69), 2.02 (1.36, 3.01), and the corresponding HRs (95% CIs) using GRS of UKB were 1.78 (1.30, 2.43), 1.94 (1.07, 3.52), and 1.74 (1.16, 2.61). The associations remained stable in the MR among the non-obese group, MVMR analysis, and MR analysis using the IVW method.</p>
Interpretation: This study suggests that, among Chinese adults, genetically predicted snoring could increase the risk of total stroke, IS, and HS, and the causal effect was independent of BMI.</p>
Funding: National Natural Science Foundation of China, Kadoorie Charitable Foundation Hong Kong, UK Wellcome Trust, National Key R&D Program of China, Chinese Ministry of Science and Technology.</p>
177 Authors
- Yunqing Zhu
- Zhenhuang Zhuang
- Jun Lv
- Dianjianyi Sun
- Pei Pei
- Ling Yang
- Iona Y. Millwood
- Robin G. Walters
- Yiping Chen
- Huaidong Du
- Xianping Wu
- Dan Schmidt
- Daniel Avery
- Junshi Chen
- Zhengming Chen
- Liming Li
- Canqing Yu
- Junshi Chen
- Zhengming Chen
- Robert Clarke
- Rory Collins
- Yu Guo
- Liming Li
- Jun Lv
- Richard Peto
- Robin Walter
- Daniel Avery
- Derrick Bennett
- Ruth Boxall
- Sue Burgess
- Ka Hung Chan
- Yumei Chang
- Yiping Chen
- Ningyu Chen
- Johnathan Clarke
- Robert Clarke
- Huaidong Du
- Ahmed Edris Mohamed
- Zammy Fairhurst-Hunter
- Hannah Fry
- Mike Hill
- Michael Holmes
- Pek Kei Im
- Andri Iona
- Maria Kakkoura
- Christiana Kartsonaki
- Rene Kerosi
- Kuang Lin
- Mohsen Mazidi
- Iona Millwood
- Sam Morris
- Qunhua Nie
- Alfred Pozarickij
- Paul Ryder
- Saredo Said
- Dan Schmidt
- Paul Sherliker
- Becky Stevens
- Iain Turnbull
- Robin Walters
- Lin Wang
- Neil Wright
- Ling Yang
- Xiaoming Yang
- Pang Yao
- Zhendong Guo
- Xiao Han
- Can Hou
- Silu Lv
- Pei Pei
- Chao Liu
- Canqing Yu
- Qingmei Xia
- Zengchang Pang
- Ruqin Gao
- Shanpeng Li
- Haiping Duan
- Shaojie Wang
- Yongmei Liu
- Ranran Du
- Yajing Zang
- Liang Cheng
- Xiaocao Tian
- Hua Zhang
- Yaoming Zhai
- Feng Ning
- Xiaohui Sun
- Feifei Li
- Silu Lv
- Junzheng Wang
- Wei Hou
- Wei Sun
- Shichun Yan
- Xiaoming Cui
- Chi Wang
- Zhenyuan Wu
- Yanjie Li
- Quan Kang
- Huiming Luo
- Tingting Ou
- Xiangyang Zheng
- Zhendong Guo
- Shukuan Wu
- Yilei Li
- Huimei Li
- Ming Wu
- Yonglin Zhou
- Jinyi Zhou
- Ran Tao
- Jie Yang
- Jian Su
- Fang Liu
- Jun Zhang
- Yihe Hu
- Yan Lu
- Liangcai Ma
- Aiyu Tang
- Shuo Zhang
- Jianrong Jin
- Jingchao Liu
- Mei Lin
- Zhenzhen Lu
- Lifang Zhou
- Changping Xie
- Jian Lan
- Tingping Zhu
- Yun Liu
- Liuping Wei
- Liyuan Zhou
- Xiaofang Chen
- Yulu Qin
- Sisi Wang
- Xianping Wu
- Ningmei Zhang
- Faqing Chen
- Xiaoyu Chang
- Mingqiang Yuan
- Xia Wu
- Lingli Chen
- Wei Jiang
- Jiaqiu Liu
- Qiang Sun
- Jianwei Chen
- Xiaolan Ren
- Caixia Dong
- Hui Zhang
- Enke Mao
- Xiaoping Wang
- Tao Wang
- Xi zhang
- Kai Kang
- Shixian Feng
- Huizi Tian
- Lei Fan
- XiaoLin Li
- Huarong Sun
- Pan He
- Xukui Zhang
- Min Yu
- Ruying Hu
- Hao Wang
- Xiaoyi Zhang
- Yuan Cao
- Kaixu Xie
- Lingli Chen
- Dun Shen
- Xiaojun Li
- Donghui Jin
- Li Yin
- Huilin Liu
- Zhongxi Fu
- Xin Xu
- Hao Zhang
- Jianwei Chen
- Yuan Peng
- Libo Zhang
- Chan Qu
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