| Title: | Common infections and neuroimaging markers of dementia in three UK cohort studies |
| Journal: | Alzheimer's & Dementia |
| Published: | 22 Jan 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38248636/ |
| DOI: | https://doi.org/10.1002/alz.13613 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.13613 |
Publication 8899
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Abstract
INTRODUCTION: We aimed to investigate associations between common infections and neuroimaging markers of dementia risk (brain volume, hippocampal volume, white matter lesions) across three population-based studies.</p>
METHODS: We tested associations between serology measures (pathogen serostatus, cumulative burden, continuous antibody responses) and outcomes using linear regression, including adjustments for total intracranial volume and scanner/clinic information (basic model), age, sex, ethnicity, education, socioeconomic position, alcohol, body mass index, and smoking (fully adjusted model). Interactions between serology measures and apolipoprotein E (APOE) genotype were tested. Findings were meta-analyzed across cohorts (Nmain = 2632; NAPOE-interaction = 1810).</p>
RESULTS: Seropositivity to John Cunningham virus associated with smaller brain volumes in basic models (β = -3.89 mL [-5.81, -1.97], Padjusted < 0.05); these were largely attenuated in fully adjusted models (β = -1.59 mL [-3.55, 0.36], P = 0.11). No other relationships were robust to multiple testing corrections and sensitivity analyses, but several suggestive associations were observed.</p>
DISCUSSION: We did not find clear evidence for relationships between common infections and markers of dementia risk. Some suggestive findings warrant testing for replication.</p>
10 Authors
- Rebecca E. Green
- Carole H. Sudre
- Charlotte Warren-Gash
- Julia Butt
- Tim Waterboer
- Alun D. Hughes
- Jonathan M. Schott
- Marcus Richards
- Nish Chaturvedi
- Dylan M. Williams
1 Application
| Application ID | Title |
|---|---|
| 71702 | Exploring the multifactorial nature of age-related health deterioration |
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