| Title: | Dietary carbohydrate types, genetic predisposition, and risk of adult-onset asthma: A longitudinal cohort study |
| Journal: | International Journal of Biological Macromolecules |
| Published: | 28 Jan 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38290630/ |
| DOI: | https://doi.org/10.1016/j.ijbiomac.2024.129824 |
Publication 8857
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Abstract
We aimed to investigate the longitudinal associations among carbohydrate intake types, genetic predisposition, and risk adult onset asthma (AOA). A dataset of 96,487 participants from UK Biobank was included with 1830 cases of incident AOA during an average follow-up of 9.68 years. Participants with the highest intake of total sugar, free sugar, and fiber intake, as compared to those with the lowest intake of total sugar, free sugar, and fiber intake, showed a 17 % and 22 % increased risk of incident AOA, and a 16 % decreased risk of AOA, respectively. Substitution of 5 % energy from free sugars with 5 % energy from non-free sugars was associated with a significantly lower risk of AOA (Hazard Ratio [HR] = 0.93, 95 % Confidence Interval [CI]: 0.88, 0.99). Participants with high genetic risk and the highest intake of free sugar showed a 112 % (HR = 2.12, 95%CI: 1.68, 2.68) increased risk of incident AOA. Participants with low genetic risk and highest intake of fiber showed a 50 % (HR = 0.50, 95%CI: 0.39, 0.64) reduced risk of AOA. This study highlights the critical role of carbohydrate types in AOA prevention, with an emphasis on reduced free sugar, moderate non-free sugar, and increased fiber intake.</p>
8 Authors
- Hehua Zhang
- Xiangsu Zhang
- Huijun Yang
- Honghao Yang
- Tingjing Zhang
- Liangkai Chen
- Yuhong Zhao
- Yang Xia
1 Application
| Application ID | Title |
|---|---|
| 63454 | Understand the relationship between diet, lifestyle and gene-environment interactions and healthy aging |
Enabling scientific discoveries that improve human health