| Title: | The association between METS-IR, an indirect index for insulin resistance, and lung cancer risk |
| Journal: | European Journal of Public Health |
| Published: | 31 Jan 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38300233/ |
| DOI: | https://doi.org/10.1093/eurpub/ckad234 |
| URL: | https://academic.oup.com/eurpub/advance-article-pdf/doi/10.1093/eurpub/ckad234/56533179/ckad234.pdf |
Publication 8845
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: Insulin resistance has been reported to increase the risk of breast, prostate and colorectal cancer. However, the role of insulin resistance and its interaction with genetic risk in the development of lung cancer remains controversial. Therefore, we aimed to explore the association between a novel metabolic score for insulin resistance (METS-IR) and lung cancer risk.</p>
METHODS: A total of 395 304 participants without previous cancer at baseline were included. The Cox proportional hazards regression model was performed to investigate the association between METS-IR and lung cancer risk. In addition, a Mendelian randomization analysis was also performed to explore the causal relationship. The joint effects and additive interactions between METS-IR and polygenetic risk score (PRS) of lung cancer were also investigated.</p>
RESULTS: During a median follow-up of 11.03 years (Inter-quartile range (IQR): 10.30-11.73), a total of 3161 incident lung cancer cases were diagnosed in 395 304 participants. There was a significant association between METS-IR and lung cancer risk, with an HR of 1.28 (95% CI: 1.17-1.41). Based on the Mendelian randomization analysis, however, no causal associations were observed. We observed a joint effect but no interaction between METS-IR and genetic risk. The lung cancer incidence was estimated to be 100.42 (95% CI: 91.45-109.38) per 100 000 person-year for participants with a high METS-IR and PRS, while only 42.76 (95% CI: 36.94-48.59) with low METS-IR and PRS.</p>
CONCLUSIONS: High METS-IR was significantly associated with an increased risk of lung cancer. Keeping a low level of METS-IR might help reduce the long-term incident risk of lung cancer.</p>
13 Authors
- Guoqing Wang
- Zhaopeng Zhu
- Yi Wang
- Qiang Zhang
- Yungang Sun
- Guanlian Pang
- Wenjing Ge
- Zhimin Ma
- Huimin Ma
- Linnan Gong
- Hongxia Ma
- Feng Shao
- Meng Zhu
1 Application
| Application ID | Title |
|---|---|
| 48700 | Polygenic risk scores for risk assessment of lung cancer in the UK Biobank and China Kadoorie Biobank |
Enabling scientific discoveries that improve human health