| Title: | Long-term ambient air pollution and the risk of musculoskeletal diseases: A prospective cohort study |
| Journal: | Journal of Hazardous Materials |
| Published: | 1 Feb 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38310839/ |
| DOI: | https://doi.org/10.1016/j.jhazmat.2024.133658 |
Publication 8806
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Evidence of the associations of air pollution and musculoskeletal diseases is inconsistent. This study aimed to examine the associations between air pollutants and the risk of incident musculoskeletal diseases, such as degenerative joint diseases (n = 38,850) and inflammatory arthropathies (n = 20,108). An air pollution score was constructed to assess the combined effect of PM2.5, PM2.5-10, NO2, and NOX. Cox proportional hazard model was applied to assess the relationships between air pollutants and the incidence of each musculoskeletal disease. The air pollution scores exhibited the modest association with an increased risk of osteoporosis (HR = 1.006, 95% CI: 1.002-1.011). Among the individual air pollutants, PM2.5 and PM2.5-10 exhibited the most significant effect on elevated risk of musculoskeletal diseases, such as PM2.5 on osteoporosis (HR = 1.064, 95% CI: 1.020-1.110), PM2.5-10 on inflammatory arthropathies (HR = 1.059, 95% CI: 1.037-1.081). Females were found to have a higher risk of incident musculoskeletal diseases when exposed to air pollutants. Individuals with extreme BMI or lower socioeconomic status had a higher risk of developing musculoskeletal diseases. Our findings reveal that long-term exposure to ambient air pollutants may contribute to an increased risk of musculoskeletal diseases.</p>
14 Authors
- Bolun Cheng
- Chuyu Pan
- Qingqing Cai
- Li Liu
- Shiqiang Cheng
- Xuena Yang
- Peilin Meng
- Wenming Wei
- Dan He
- Huan Liu
- Yumeng Jia
- Yan Wen
- Peng Xu
- Feng Zhang
1 Application
| Application ID | Title |
|---|---|
| 46478 | Multi-omics integrative studies of common psychiatric disorders and skeletal disorders |
Enabling scientific discoveries that improve human health