| Title: | Accelerometer-measured physical activity, sedentary behavior, and risk of incident pelvic organ prolapse: a prospective cohort study in the UK Biobank |
| Journal: | International Journal of Behavioral Nutrition and Physical Activity |
| Published: | 2 Feb 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38308373/ |
| DOI: | https://doi.org/10.1186/s12966-024-01559-w |
| URL: | https://ijbnpa.biomedcentral.com/counter/pdf/10.1186/s12966-024-01559-w |
Publication 8798
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Abstract
BackgroundPrevious studies on physical activity (PA) and pelvic organ prolapse (POP) were largely limited to self-reported PA in athletes, soldiers, and women in postpartum. We aimed to investigate the association of accelerometer-measured PA and sedentary behavior with the risk of POP in middle-aged and elderly women.MethodsIn this prospective cohort derived from the UK Biobank, the intensity and duration of PA and sedentary behavior were measured with wrist-worn accelerometers over a 7-day period in 2013-2015 for 47,674 participants (aged 42.8-77.9 years) without pre-existing POP. Participants were followed up until the end of 2022, during which incident POP was ascertained mainly by the electronic health records. Multivariable-adjusted Cox proportional hazards models and restricted cubic splines were used to assess the associations of interest. Isotemporal substitution models were applied to test the effects of substituting a type of activity with equivalent duration of others.ResultsDuring a median follow-up of 8.0 years, 779 cases of POP were recorded. The duration of light-intensity PA (LPA) was positively whereas sedentary time was negatively associated with the risk of POP. Every additional 1 h/day of LPA elevated the risk of POP by 18% (95% confidence interval [CI], 10%-26%). In contrast, the risk decreased by 5% (95% CI, 0-8%) per 1 h/day increment in sedentary behavior. No associations were found between moderate-intensity PA (MPA) or vigorous-intensity PA (VPA) and POP, except that women who had a history of hysterectomy were more likely to develop POP when performing more VPA (53% higher risk for every additional 15 min/day). Substituting 1 h/day of LPA with equivalent sedentary time was associated with a 18% (95% CI, 11%-24%) lower risk of POP. The risk can also be reduced by 17% (95% CI, 7%-25%) through substituting 30 min/day of LPA with MPA.ConclusionsMore time spent in LPA or less sedentary time was linked to an elevated risk of POP in middle-aged and elderly women, while MPA or VPA was not. Substituting LPA with equivalent duration of sedentary behavior or MPA may lower the risk of POP.</p>
9 Authors
- Keyi Si
- Zhi Cao
- Qianqian Liu
- Yingying Yang
- Qingqiang Dai
- Yuting Yao
- Yingying Qiao
- Chenjie Xu
- Guizhu Wu
1 Application
| Application ID | Title |
|---|---|
| 79095 | Dietary patterns and lifestyle-related factors with human immunity and multimorbidity burden |
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