| Title: | The role of cardiac remodeling associated with renal function in mediating cardiovascular event outcomes |
| Journal: | iScience |
| Published: | 5 Feb 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38384844/ |
| DOI: | https://doi.org/10.1016/j.isci.2024.109143 |
| URL: | http://www.cell.com/article/S258900422400364X/pdf |
Publication 8785
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Abstract
The potential impact of renal function-related cardiovascular remodeling on associated cardiovascular risk has not been previously investigated. Hence, we conducted multiple mediation analyses in the UK Biobank study to evaluate this association. Using multiple Cox models, we found lower renal function (estimated glomerular filtration rate based on cystatin C, eGFR-cysC) was independently related to increased risks of various cardiovascular events and mortalities. Multivariable linear regression revealed a progressive relationship between declining eGFR-cysC and adverse left ventricular (LV) remodeling and impaired systolic function. In Cox models, larger LV volume, mass, as well as decreased systolic function, were significantly correlated with adverse events, particularly in heart failure. Mediation analyses showed that undesirable LV remodeling and cardiometabolic diseases were independent mediators. Our study explores the connections between reduced renal function and poor cardiovascular phenotypes, as well as their significant independent role in mediating renal function-cardiovascular outcome relationships.</p>
7 Authors
- Zhi Lv
- Yangzhi Fu
- Chang Liu
- Yao Ma
- Miao Yuan
- Junru Ren
- Dengfeng Gao
1 Application
| Application ID | Title |
|---|---|
| 68722 | The relationship and genetic association of high resting heart rate and myocardial remodeling |
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