| Title: | Association between Daytime Napping and Incident Arrhythmias: A Prospective Cohort Study and a Mendelian Randomization Analysis |
| Journal: | Heart Rhythm |
| Published: | 7 Feb 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38336194/ |
| DOI: | https://doi.org/10.1016/j.hrthm.2024.02.004 |
Publication 8771
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Abstract
BACKGROUND: Emerging evidence has linked daytime napping with the risk of cardiovascular events. Cardiac arrhythmias are considered as early-stage clinical stage for cardiovascular diseases. However, whether napping frequency is associated with incident arrhythmias remains unknown.</p>
OBJECTIVE: This study aims to prospectively investigate the association between napping frequency and cardiac arrhythmias.</p>
METHODS: Daytime napping frequency was self-reported in response to touchscreen questionnaires. The primary outcomes were incident arrhythmias, including atrial fibrillation/flutter (AF/Af), ventricular arrhythmias, and bradyarrhythmia. Cox regression analysis was conducted based on 491,117 participants free of cardiac arrhythmias from UK Biobank (UKB). The two-sample Mendelian randomization (MR) and one-sample MR were used to ensure a causal effect of genetically predicted daytime napping on the risk of arrhythmias.</p>
RESULTS: During a median follow-up of 11.91 years, 28,801 incident AF/Af, 4,132 incident ventricular arrhythmias, and 11,616 incident bradyarrhythmia were documented. Compared with never/rarely napping, usually napping was significantly associated with higher risks of AF/Af (HR: 1.141; 95% CI: 1.083-1.203)) and bradyarrhythmia (HR: 1.138; 95% CI: 1.049-1.235), but not ventricular arrhythmias, after adjustment for various covariates. The two-sample MR and one-sample MR analysis showed that increased daytime napping frequency was likely to be a potential causal risk factor for AF/Af in FinnGEN (OR, 1.626; 95% CI, 1.061-2.943) and bradyarrhythmia in UKB (OR, 1.005, 95% CI, 1.002-1.008).</p>
CONCLUSIONS: The results of this study add to the burgeoning evidence of an association between daytime napping frequency and an increased risk of cardiac arrhythmias including AF/Af, ventricular arrhythmias, and bradyarrhythmia.</p>
13 Authors
- Qing-Yuan Gao
- Hai-Feng Zhang
- Jing-Wei Gao
- Jie-Wen Cai
- Qian Chen
- Si You
- Zhi-Teng Chen
- Da-Chuan Guo
- Shu-Tai Li
- Qing-Yun Hao
- Pin-Ming Liu
- Jing-Feng Wang
- Yang-Xin Chen
1 Application
| Application ID | Title |
|---|---|
| 91090 | Predictors of coronary artery calcification (CAC) progression in the UKB population |
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