Title: | Female reproductive histories and the risk of chronic obstructive pulmonary disease |
Journal: | Thorax |
Published: | 13 Feb 2024 |
Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38350732/ |
DOI: | https://doi.org/10.1136/thorax-2023-220388 |
Title: | Female reproductive histories and the risk of chronic obstructive pulmonary disease |
Journal: | Thorax |
Published: | 13 Feb 2024 |
Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38350732/ |
DOI: | https://doi.org/10.1136/thorax-2023-220388 |
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
BACKGROUND: Female reproductive factors may influence the development of chronic obstructive pulmonary disease (COPD) through the female hormonal environment, but studies on this topic are limited. This study aimed to assess whether age at menarche, number of children, infertility, miscarriage, stillbirth and age at natural menopause were associated with the risk of COPD.</p>
METHODS: Women from three cohorts with data on reproductive factors, COPD and covariates were included. Cause specific Cox regression models were adjusted for birth year, race, educational level, body mass index and pack years of smoking, stratified by asthma, and incorporating interaction between birth year and time. Between cohort differences and within cohort correlations were taken into account.</p>
RESULTS: Overall, 2 83 070 women were included and 10 737 (3.8%) developed COPD after a median follow-up of 11 (IQR 10-12) years. Analyses revealed a U shaped association between age at menarche and COPD (≤11 vs 13: HR 1.17, 95% CI 1.11 to 1.23; ≥16 vs 13: HR 1.24, 95% CI 1.21 to 1.27). Women with three or more children (3 vs 2: HR 1.14, 95% CI 1.12 to 1.17; ≥4 vs 2: HR 1.34, 95% CI 1.28 to 1.40), multiple miscarriages (2 vs 0: HR 1.28, 95% CI 1.24 to 1.32; ≥3 vs 0: HR 1.36, 95% CI 1.30 to 1.43) or stillbirth (1 vs 0: HR 1.38, 95% CI 1.25 to 1.53; ≥2 vs 0: HR 1.67, 95% CI 1.32 to 2.10) were at a higher risk of COPD. Among postmenopausal women, earlier age at natural menopause was associated with an increased risk of COPD (<40 vs 50-51: HR 1.69, 95% CI 1.63 to 1.75; 40-44 vs 50-51: HR 1.42, 95% CI 1.38 to 1.47).</p>
CONCLUSIONS: Multiple female reproductive factors, including age at menarche, number of children, miscarriage, stillbirth, and age at natural menopause were associated with the risk of COPD.</p>
Application ID | Title |
---|---|
26629 | Cross-cultural variations in female reproductive health and non-communicable diseases: analysis of 500,000 participants from the UKBiobank and the InterLACE consortium |
Enabling scientific discoveries that improve human health