| Title: | Racial Differences in Bleeding Risk: An Ecological Epidemiological Study Comparing Korea and United Kingdom Subjects |
| Journal: | Thrombosis and Haemostasis |
| Published: | 15 Feb 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38359877/ |
| DOI: | https://doi.org/10.1055/a-2269-1123 |
| URL: | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-2269-1123.pdf |
Publication 8725
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Abstract
BACKGROUND: This study aimed to evaluate racial differences in bleeding incidence by conducting an ecological epidemiological study using data from Korea and the UK.</p>
METHODS: We included healthy participants from the Korean National Health Insurance Service-Health Screening and the UK Biobank who underwent health examinations between 2006 and 2010 and had no comorbidities or history of medication use. Finally, 112,750 East Asians (50.7% men, mean age 52.6 years) and 210,995 Caucasians (44.7% men, mean age 55.0 years) were analyzed. The primary outcome was composed of intracranial hemorrhage (ICH) and bleeding from the gastrointestinal, respiratory, and genitourinary systems.</p>
RESULTS: During the follow-up, primary outcome events occurred in 2110 East Asians and in 6515 Caucasians. East Asians had a 38% lower five-year incidence rate compared to Caucasians (3.88 vs. 6.29 per 1000 person-years; incidence rate ratio [IRR] 0.62, 95% confidence interval [CI] 0.59-0.65). East Asians showed a lower incidence of major bleeding (IRR 0.86, 95% CI 0.81-0.91), bleeding from the gastrointestinal (IRR 0.53, 95% CI 0.49-0.56), and genitourinary systems (IRR 0.49, 95% CI 0.44-0.53) compared to Caucasians. The incidence rates of ICH (IRR 3.20, 95% CI 2.67-3.84) and bleeding from the respiratory system (IRR 1.28, 95% CI 1.11-1.47) were higher in East Asians. East Asians consuming alcohol ≥3 times/week showed a higher incidence of the primary outcome than Caucasians (IRR 1.12, 95% CI 1.01-1.25).</p>
CONCLUSIONS: This ecological study revealed significant racial differences in bleeding incidence, influenced by anatomical sites and lifestyle habits, underscoring the need for race-specific holistic approaches in bleeding management.</p>
11 Authors
- Dong-Seon Kang
- Pil-Sung Yang
- Daehoon Kim
- Eunsun Jang
- Hee Tae Yu
- Tae-Hoon Kim
- Jung Hoon Sung
- Hui-Nam Pak
- Moon-Hyoung Lee
- Gregory Y.H. Lip
- Boyoung Joung
1 Application
| Application ID | Title |
|---|---|
| 77793 | The causal inference study to determine the association of genetically predicted biological, behavioral, ethnic factors with risk of atrial fibrillation and its associated complications. |
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