| Title: | Frailty mediating the causality between leucocyte telomere length and mortality: a cohort study of 440,551 UK Biobank participants |
| Journal: | EPMA Journal |
| Published: | 15 Feb 2024 |
| DOI: | https://doi.org/10.1007/s13167-024-00355-7 |
Publication 8723
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Abstract
IntroductionPrevious studies reported leucocyte telomere length (LTL) and frailty were associated with mortality, but it remains unclear whether frailty serves as a mediator in the relationship between leucocyte telomere length and mortality risk. This study aimed to evaluate how measuring LTL and frailty can support early monitoring and prevention of risk of mortality from the prospective of predictive, preventive, and personalized medicine (PPPM/3PM).MethodsWe included 440,551 participants from the UK Biobank between the baseline visit (2006-2010) and November 30, 2022. The time-dependent Cox proportional hazards model was conducted to assess the association between LTL and frailty index with the risk of mortality. Furthermore, we conducted causal mediation analyses to examine the extent to which frailty mediated the association between LTL and mortality.ResultsDuring a median follow-up of 13.74 years, each SD increase in LTL significantly decreased the risk of all-cause [hazard ratio (HR): 0.94, 95% confidence interval (CI): 0.93-0.95] and CVD-specific mortality (HR: 0.92, 95% CI: 0.90-0.95). The SD increase in FI elevated the risk of all-cause (HR: 1.35, 95% CI: 1.34-1.36), CVD-specific (HR: 1.47, 95% CI: 1.44-1.50), and cancer-specific mortality (HR: 1.22, 95% CI: 1.20-1.24). Frailty mediated approximately 10% of the association between LTL and all-cause and CVD-specific mortality.ConclusionsOur results indicate that frailty mediates the effect of LTL on all-cause and CVD-specific mortality. There findings might be valuable to predict, prevent, and reduce mortality through primary prevention and healthcare in context of PPPM.</p>
9 Authors
- Xuening Jian
- Wenxin Sun
- Jie Zhang
- Qiaoyun Zhang
- Xiaoni Meng
- Huimin Lu
- Deqiang Zheng
- Lijuan Wu
- Youxin Wang
1 Application
| Application ID | Title |
|---|---|
| 95259 | The role of dynamic environmental factors, genetic information, and gene-environment interactions in non-communicable chronic diseases and the development and validation of prediction models for risks |
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