| Title: | Roles of gut microbiota in atrial fibrillation: insights from Mendelian randomization analysis and genetic data from over 430,000 cohort study participants |
| Journal: | Cardiovascular Diabetology |
| Published: | 8 Nov 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37940997/ |
| DOI: | https://doi.org/10.1186/s12933-023-02045-6 |
| URL: | https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-023-02045-6 |
Publication 8367
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Abstract
BackgroundGut microbiota imbalances have been suggested as a contributing factor to atrial fibrillation (AF), but the causal relationship is not fully understood.ObjectivesTo explore the causal relationships between the gut microbiota and AF using Mendelian randomization (MR) analysis.MethodsSummary statistics were from genome-wide association studies (GWAS) of 207 gut microbial taxa (5 phyla, 10 classes, 13 orders, 26 families, 48 genera, and 105 species) (the Dutch Microbiome Project) and two large meta-GWASs of AF. The significant results were validated in FinnGen cohort and over 430,000 UK Biobank participants. Mediation MR analyses were conducted for AF risk factors, including type 2 diabetes, coronary artery disease (CAD), body mass index (BMI), blood lipids, blood pressure, and obstructive sleep apnea, to explore the potential mediation effect of these risk factors in between the gut microbiota and AF.ResultsTwo microbial taxa causally associated with AF: species Eubacterium ramulus (odds ratio [OR] 1.08, 95% confidence interval [CI] 1.04-1.12, P = 0.0001, false discovery rate (FDR) adjusted p-value = 0.023) and genus Holdemania (OR 1.15, 95% CI 1.07-1.25, P = 0.0004, FDR adjusted p-value = 0.042). Genus Holdemania was associated with incident AF risk in the UK Biobank. The proportion of mediation effect of species Eubacterium ramulus via CAD was 8.05% (95% CI 1.73% − 14.95%, P = 0.008), while the proportion of genus Holdemania on AF via BMI was 12.01% (95% CI 5.17% − 19.39%, P = 0.0005).ConclusionsThis study provided genetic evidence to support a potential causal mechanism between gut microbiota and AF and suggested the mediation role of AF risk factors.</p>
19 Authors
- Huajie Dai
- Tianzhichao Hou
- Qi Wang
- Yanan Hou
- Zheng Zhu
- Yijie Zhu
- Zhiyun Zhao
- Mian Li
- Hong Lin
- Shuangyuan Wang
- Ruizhi Zheng
- Yu Xu
- Jieli Lu
- Tiange Wang
- Guang Ning
- Weiqing Wang
- Jie Zheng
- Yufang Bi
- Min Xu
1 Application
| Application ID | Title |
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| 64754 | Lipoprotein (a) and risk of clinical outcomes including chronic kidney disease, cardiovascular diseases and cancers among different glycemic status: an interactive and prospective analysis |
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