| Title: | Actigraphy-derived measures of sleep and risk of prostate cancer in the UK Biobank |
| Journal: | Journal of the National Cancer Institute |
| Published: | 28 Nov 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38013591/ |
| DOI: | https://doi.org/10.1093/jnci/djad210 |
| URL: | https://academic.oup.com/jnci/advance-article-pdf/doi/10.1093/jnci/djad210/53811065/djad210.pdf |
Publication 8242
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Abstract
BACKGROUND: Studies of sleep and prostate cancer are almost entirely based on self-report, with limited research using actigraphy. Our goal was to evaluate actigraphy-measured sleep and prostate cancer and to expand on findings from prior studies of self-reported sleep.</p>
METHODS: We prospectively examined 34 260 men without a history of prostate cancer in the UK Biobank. Sleep characteristics were measured over 7 days using actigraphy. We calculated sleep duration, onset, midpoint, wake-up time, social jetlag (difference in weekend-weekday sleep midpoints), sleep efficiency (percentage of time spent asleep between onset and wake-up time), and wakefulness after sleep onset. Cox proportional hazards models were used to estimate covariate-adjusted hazards ratios (HRs) and 95% confidence intervals (CIs).</p>
RESULTS: Over 7.6 years, 1152 men were diagnosed with prostate cancer. Sleep duration was not associated with prostate cancer risk. Sleep midpoint earlier than 4:00 am was not associated with prostate cancer risk, though sleep midpoint of 5:00 am or later was suggestively associated with lower prostate cancer risk but had limited precision (earlier than 4:00 am vs 4:00-4:59 am HR = 1.00, 95% CI = 0.87 to 1.16; 5:00 am or later vs 4:00-4:59 am HR = 0.79, 95% CI = 0.57 to 1.10). Social jetlag was not associated with greater prostate cancer risk (1 to <2 hours vs <1 hour HR = 1.06, 95% CI = 0.89 to 1.25; ≥2 hours vs <1 hour HR = 0.90, 95% CI = 0.65 to 1.26). Compared with men who averaged less than 30 minutes of wakefulness after sleep onset per day, men with 60 minutes or more had a higher risk of prostate cancer (HR = 1.20, 95% CI = 1.00 to 1.43).</p>
CONCLUSIONS: Of the sleep characteristics studied, higher wakefulness after sleep onset-a measure of poor sleep quality-was associated with greater prostate cancer risk. Replication of our findings between wakefulness after sleep onset and prostate cancer are warranted.</p>
12 Authors
- Joshua R Freeman
- Pedro F Saint-Maurice
- Eleanor L Watts
- Steven C Moore
- Marissa M Shams-White
- Dana L Wolff-Hughes
- Daniel E Russ
- Jonas S Almeida
- Neil E Caporaso
- Hyokyoung G Hong
- Erikka Loftfield
- Charles E Matthews
1 Application
| Application ID | Title |
|---|---|
| 43456 | Association of physical activity, fitness, and obesity with cancer incidence and mortality. |
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