| Title: | Role of residential greenspace in the trajectory of major neurological disorders: A longitudinal study in UK Biobank |
| Journal: | The Science of The Total Environment |
| Published: | 1 Dec 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38042194/ |
| DOI: | https://doi.org/10.1016/j.scitotenv.2023.168967 |
Publication 8225
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Abstract
BACKGROUND: Stroke and dementia are major neurological disorders that contribute significantly to disease burden and are interlinked in terms of risk. Nevertheless, there is currently no study investigating the influence of residential greenspace on the trajectory of these neurological disorders.</p>
METHODS: This longitudinal study utilized data from the UK Biobank. Exposure to residential greenspace was measured by the percentage of total greenspace coverage within a 300-meter buffer zone surrounding the participants' residences. A multistate model was employed to illustrate the trajectory of major neurological disorders, and a piecewise Cox regression model was applied to explore the impact of residential greenspace on different time courses of disease transitions.</p>
RESULTS: With 422,649 participants and a median follow-up period of 12.5 years, 8568 (2.0 %), 5648 (1.3 %), and 621 (0.1 %) individuals developed incident stroke, dementia, and comorbidity of both conditions, respectively. An increase in residential greenspace by one interquartile range was associated with reduced risks of transitions from baseline to stroke, dementia, and death, as well as from stroke to comorbidity. The corresponding hazard ratios (HRs) were 0.967 (95 % CI: 0.936, 0.998), 0.928 (0.892, 0.965), 0.925 (0.907, 0.942), and 0.799 (0.685, 0.933), respectively. Furthermore, the protective effect of residential greenspace on the transition from stroke or dementia to comorbidity was particularly pronounced within the first year and over 5 years after stroke and during the 2 to 3 years after dementia onset, with HRs of 0.692 (0.509, 0.941), 0.705 (0.542, 0.918), and 0.567 (0.339, 0.949), respectively.</p>
CONCLUSION: This study observed a protective role of residential greenspace in the trajectory of major neurological disorders and contributed to identifying critical progression windows. These findings underscore the significance of environment-health interactions in the prevention of neurological disorders.</p>
9 Authors
- Xin Hu
- Jiawei Wang
- Teng Yang
- Jianbo Jin
- Qiang Zeng
- Omid Aboubakri
- Xing Lin Feng
- Guoxing Li
- Jing Huang
1 Application
| Application ID | Title |
|---|---|
| 83167 | Health risks of chronic diseases associated with meteorological index and air pollutants: evaluation and projections under different climate change scenarios |
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